High impact information on SLC38A4

• The 2.9-kb ATB(0) mRNA was equally expressed in all cell lines, whereas expression of the system A transporters ATA2 and ATA3 was variable [1].
• Using fluorescence in situ hybridization, we mapped the hNAT3 gene to human chromosome 12q12-q13 [2].
• The genomic DNA sequence encoding the transcript of hNAT3 spans over 14 kb with 16 exons and 15 introns [2].
• CONCLUSION: This is the first report on the imprinting status of SLC38A4, NAP1L5, and on the expression patterns of the two transcripts of NNAT in cattle [3].
• The human ATA3 (hATA3) exhibits 88% identity in amino acid sequence with rat ATA3 [4].

Anatomical context of SLC38A4

• We report here on the cloning and functional characterization of the third subtype of amino acid transport system A, designated ATA3 (amino acid transporter A3), from a human liver cell line [4].

Associations of SLC38A4 with chemical compounds

• Since liver does not express any of the previously known high-affinity cationic amino acid transporters, ATA3 is likely to provide the major route for the uptake of arginine in this tissue [4].

Analytical, diagnostic and therapeutic context of SLC38A4

• The overall PAAT index for subjects scoring at either the upper or lower extremes proved to be valuable in identifying those parents who would be the most and least successful teachers in a home-based language training program [5].

References