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ARHGAP17  -  Rho GTPase activating protein 17

Homo sapiens

Synonyms: FLJ10308, FLJ13219, MST066, MST110, MSTP038, ...
 
 
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Disease relevance of ARHGAP17

  • Virucidal Activity of a GT-Rich Oligonucleotide against Herpes Simplex Virus Mediated by Glycoprotein B [1].
  • Secreted Protein, Acidic and Rich in Cysteine (SPARC) (Osteonectins), one of the most highly expressed genes in both intestinal and diffuse gastric cancers in our microarray results, was selected for further study [2].
  • Hamman and Rich are generally considered to have been the first to describe idiopathic pulmonary fibrosis (IPF) as a new clinical and pathological entity [3].
  • METHODS: Rich and sparse pharmacokinetic data were collected prospectively from: healthy volunteers (n=48) and adults (n=65) and children (n=68) suffering from P. falciparum malaria [4].
  • OBJECTIVE: Rich and complicated vascular structures on the spinal cord often interfere with obliteration of a spinal arteriovenous malformation (AVM) [5].
 

Psychiatry related information on ARHGAP17

  • In particular I consider Judith Wallerstein's clinically based claims of the pervasive, profound harm caused by divorce and, at the other extreme, Judith Rich Harris's reading of behavioral genetics and evolutionary psychology, which leads her to dismiss the direct effects of divorce [6].
  • The aim of this study was to examine the psychometric properties of a French version of the Multifactorial Memory Questionnaire (MMQ) (Troyer and Rich, 2002) [7].
 

High impact information on ARHGAP17

  • Classics in oncology. On the frequency of occurrence of occult carcinoma of the prostate: Arnold Rice Rich, M.D., Journal of Urology 33:3, 1935 [8].
  • Regulation of Cdc42 by Rich1 is necessary for maintenance of TJs, and Rich1 is therefore an important mediator of this polarity complex [9].
  • Using functional and proteomic screens of proteins that regulate the Cdc42 GTPase, we have identified a network of protein interactions that center around the Cdc42 RhoGAP Rich1 and organize apical polarity in MDCK epithelial cells [9].
  • How molecular biology won its place in the USSR. Interview by Vera Rich [10].
  • This peptide adopts a triple-helical structure that confirms the basic features determined from fiber diffraction studies on collagen: supercoiling of polyproline II helices and interchain hydrogen bonding that follows the model II of Rich and Crick [11].
 

Biological context of ARHGAP17

  • Transient transfections of RICH-1 indicated that it bound to CIP4 in vivo, as shown by co-immunoprecipitation experiments, as well as co-localization assays [12].
  • Expression of Nadrin or its mutant composed of the coiled-coil and GAP domain enhanced Ca(2+)-dependent exocytosis of PC12 cells, but a mutant lacking the GAP domain inhibited exocytosis [13].
  • Thus a new cell-adhesion site has been identified in TS whose sequence is very similar to the site identified in region II of the circumsporozoite protein of malaria parasites (Rich, K [14].
  • Tethering KSRP, a Decay-Promoting AU-Rich Element-Binding Protein, to mRNAs Elicits mRNA Decay [15].
  • Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1-Mediated Activation of Two GC-Rich Promoter Elements [16].
 

Anatomical context of ARHGAP17

  • Expression of Nadrin in NIH3T3 cells markedly reduced the number of the actin stress fibers and the formation of the ruffled membranes, suggesting that Nadrin regulates actin filament reorganization [13].
  • Murphy, Coll, Rich and Williamson (J. Biol. Chem. 255:6600--6608, 1980) described a null-point method for estimating intracellular free Ca in liver cells [17].
  • In this study we report that in comparison to mid-zone fetal membranes biopsies, these regions are characterized by increased expression of the matricellular protein osteonectin or SPARC (Secreted Protein Acidic and Rich in Cysteine) [18].
  • Tuberculous meningitis (TBM) develops most often when a caseating meningeal or sub-cortical focus, the Rich focus, discharges its contents into the subarachnoid space [19].
  • Following previous notions (Gaskill and Brown, 1990), an analysis of basilar membrane response data in experimental animals (after Ruggero and Rich, 1991, Hear. Res. 51, 215-230) is further presented that relates optimal L(1)-L(2) separations to frequency-selective compression of the basilar membrane [20].
 

Associations of ARHGAP17 with chemical compounds

  • SPARC (Secreted Protein, Acidic, Rich in Cysteine) is expressed as a 1.6 kb mRNA in Xenopus laevis [21].
  • We have already reported that binding of cyanide to the ferrous forms of these mutants becomes too weak to be measurable [Meunier, Rodriguez-Lopez, Smith, Thorneley and Rich (1995) Biochemistry 34, 14687-14692] [22].
  • The LTX-ray data sets contain 20% (daunomycin, LT-DAUN) and 35% (adriamycin, LT-ADRI) more reflections than were used to derive the original room-temperature (15 degrees C) structures [Frederick, C.A., Williams, L.D., Ughetto, G., van der Marel, G. A., van Boom, J.H., Rich, A., & Wang, A.H.-J. (1990) Biochemistry 29, 2538-2549] [23].
  • One of the oligonucleotides, d(CGTACG), is identical to that used in the high resolution x-ray structure determination of the daunorubicin intercalative complex (Wang, A. H.-J., Ughetto, G., Quigley, G. J. & Rich, A. (1987). Biochemistry 26, 1152-1163) [24].
  • SPARC (Secreted Protein, Acidic and Rich in Cysteine)/osteonectin is a secreted glycoprotein that exhibits restricted expression in murine adult and embryonic tissues and is associated with cell migration, matrix mineralization, steroid hormone production, cell cycle regulation, and angiogenesis [25].
 

Analytical, diagnostic and therapeutic context of ARHGAP17

  • The first clinical trials of NaF therapy for osteoporosis were reported by Rich and Ensinck in 1961 [26].
  • As seen with in situ hybridization, a similar temporal pattern of expression of messenger RNAs corresponding to type I procollagen and Secreted Protein, Acidic and Rich in Cysteine (osteonectin), known to be prevalent in healing wounds, was observed in both young and aged rats [27].
  • "An approach to the treatment of severe adult respiratory failure (by Rich et al, Journal of Critical Care 13:26-36, 1998)" [28].
  • For the study, the monkeys were fed a Prudent Diet (at 0.1 mg cholesterol/cal) for 5 months preceding the ovariectomy and for 7 months after the ovariectomy followed by a Rich Diet (at 0.4 mg cholesterol/cal) for 7 months [29].

References

  1. Virucidal Activity of a GT-Rich Oligonucleotide against Herpes Simplex Virus Mediated by Glycoprotein B. Shogan, B., Kruse, L., Mulamba, G.B., Hu, A., Coen, D.M. J. Virol. (2006) [Pubmed]
  2. Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance. Wang, C.S., Lin, K.H., Chen, S.L., Chan, Y.F., Hsueh, S. Br. J. Cancer (2004) [Pubmed]
  3. Idiopathic pulmonary fibrosis: a historical review. Homolka, J. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1987) [Pubmed]
  4. Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. Simpson, J.A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., Edwards, G., Watkins, W.A., Ward, S. British journal of clinical pharmacology. (2006) [Pubmed]
  5. Vascular orientation by intra-arterial dye injection during spinal arteriovenous malformation surgery. Tani, S., Ikeuchi, S., Hata, Y., Abe, T. Neurosurgery (2001) [Pubmed]
  6. Going to extremes: family structure, children's well-being, and social science. Cherlin, A.J. Demography. (1999) [Pubmed]
  7. Psychometric properties of the French version of the multifactorial memory questionnaire for adults and the elderly. Fort, I., Adoul, L., Holl, D., Kaddour, J., Gana, K. Canadian journal on aging = La revue canadienne du vieillissement. (2004) [Pubmed]
  8. Classics in oncology. On the frequency of occurrence of occult carcinoma of the prostate: Arnold Rice Rich, M.D., Journal of Urology 33:3, 1935. Rich, A.R. CA: a cancer journal for clinicians. (1979) [Pubmed]
  9. A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells. Wells, C.D., Fawcett, J.P., Traweger, A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim, C., Colwill, K., Starostine, A., Metalnikov, P., Pawson, T. Cell (2006) [Pubmed]
  10. How molecular biology won its place in the USSR. Interview by Vera Rich. Tumerman, L. Nature (1978) [Pubmed]
  11. Crystal and molecular structure of a collagen-like peptide at 1.9 A resolution. Bella, J., Eaton, M., Brodsky, B., Berman, H.M. Science (1994) [Pubmed]
  12. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. Richnau, N., Aspenström, P. J. Biol. Chem. (2001) [Pubmed]
  13. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada, A., Furuta, B., Takeuchi, K., Itakura, M., Takahashi, M., Umeda, M. J. Biol. Chem. (2000) [Pubmed]
  14. The properdin-like type I repeats of human thrombospondin contain a cell attachment site. Prater, C.A., Plotkin, J., Jaye, D., Frazier, W.A. J. Cell Biol. (1991) [Pubmed]
  15. Tethering KSRP, a Decay-Promoting AU-Rich Element-Binding Protein, to mRNAs Elicits mRNA Decay. Chou, C.F., Mulky, A., Maitra, S., Lin, W.J., Gherzi, R., Kappes, J., Chen, C.Y. Mol. Cell. Biol. (2006) [Pubmed]
  16. Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1-Mediated Activation of Two GC-Rich Promoter Elements. Dasari, A., Bartholomew, J.N., Volonte, D., Galbiati, F. Cancer Res. (2006) [Pubmed]
  17. A method for estimating free Ca within human red blood cells, with an application to the study of their Ca-dependent K permeability. Simons, T.J. J. Membr. Biol. (1982) [Pubmed]
  18. Regional and cellular localization of osteonectin/SPARC expression in connective tissue and cytotrophoblastic layers of human fetal membranes at term. McParland, P.C., Bell, S.C., Pringle, J.H., Taylor, D.J. Mol. Hum. Reprod. (2001) [Pubmed]
  19. Tuberculous meningitis and miliary tuberculosis: the Rich focus revisited. Donald, P.R., Schaaf, H.S., Schoeman, J.F. J. Infect. (2005) [Pubmed]
  20. Optimal L(1)-L(2) primary tone level separation remains independent of test frequency in humans. Kummer, P., Janssen, T., Hulin, P., Arnold, W. Hear. Res. (2000) [Pubmed]
  21. Molecular analysis of Xenopus laevis SPARC (Secreted Protein, Acidic, Rich in Cysteine). A highly conserved acidic calcium-binding extracellular-matrix protein. Damjanovski, S., Liu, F., Ringuette, M. Biochem. J. (1992) [Pubmed]
  22. Redox- and anion-linked protonation sites in horseradish peroxidase: analysis of distal haem pocket mutants. Meunier, B., Rodriguez-Lopez, J.N., Smith, A.T., Thorneley, R.N., Rich, P.R. Biochem. J. (1998) [Pubmed]
  23. Water ring structure at DNA interfaces: hydration and dynamics of DNA-anthracycline complexes. Lipscomb, L.A., Peek, M.E., Zhou, F.X., Bertrand, J.A., VanDerveer, D., Williams, L.D. Biochemistry (1994) [Pubmed]
  24. Association of anthracyclines and synthetic hexanucleotides. Structural factors influencing sequence specificity. Rizzo, V., Battistini, C., Vigevani, A., Sacchi, N., Razzano, G., Arcamone, F., Garbesi, A., Colonna, F.P., Capobianco, M., Tondelli, L. J. Mol. Recognit. (1989) [Pubmed]
  25. Distribution of SPARC in normal and neoplastic human tissue. Porter, P.L., Sage, E.H., Lane, T.F., Funk, S.E., Gown, A.M. J. Histochem. Cytochem. (1995) [Pubmed]
  26. The role of fluoride in the prevention of osteoporosis. Kleerekoper, M. Endocrinol. Metab. Clin. North Am. (1998) [Pubmed]
  27. Acceleration of wound healing in aged rats by topical application of transforming growth factor-beta(1). Reed, M.J., Gombotz, W.R., Twardzik, D.R., Abrass, I.B., Helene Sage, E. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (1995) [Pubmed]
  28. "An approach to the treatment of severe adult respiratory failure (by Rich et al, Journal of Critical Care 13:26-36, 1998)". Morris, A.H. Journal of critical care. (1998) [Pubmed]
  29. Effect of ovariectomy on response to dietary cholesterol in patas monkeys (Erythrocebus patas). Baker, H.N., Abee, C.R. Exp. Mol. Pathol. (1987) [Pubmed]
 
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