The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PPP2CB  -  protein phosphatase 2, catalytic subunit,...

Homo sapiens

Synonyms: PP2A-beta, PP2Abeta, PP2CB, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PPP2CB

  • This low level of PP2A protein was reflected at a relative deficiency in expression of the PP2A beta gene in HL-60RAr cells [1].
  • The mRNA level of PP2A beta was markedly decreased within 5 h after addition of ATRA, but there was only a slight increase in the mRNA level of PP2A alpha [2].
  • Selective down-regulation of PP2A beta mRNA clearly preceded the cell differentiation induced by ATRA treatment [2].
  • Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer [3].
  • Also mapped to this region (8p12-p11.2) is the gene encoding the beta isoform of the catalytic subunit of protein phosphatase 2A (PPP2CB), a major serine/threonine phosphatase thought to play a regulatory role in many cellular pathways [3].
 

Biological context of PPP2CB

 

Analytical, diagnostic and therapeutic context of PPP2CB

References

  1. Decreased expression of protein phosphatase type 2A in HL-60 variant (HL-60RAr) cells resistant to induction of cell differentiation by all-trans retinoic acid. Omay, S.B., Nishikawa, M., Morita, K., Toyoda, H., Nakai, K., Shima, H., Nagao, M., Kitagawa, S., Saito, M., Shiku, H. Exp. Hematol. (1995) [Pubmed]
  2. Down-regulation by retinoic acid of the catalytic subunit of protein phosphatase type 2A during granulocytic differentiation of HL-60 cells. Tawara, I., Nishikawa, M., Morita, K., Kobayashi, K., Toyoda, H., Omay, S.B., Shima, H., Nagao, M., Kuno, T., Tanaka, C. FEBS Lett. (1993) [Pubmed]
  3. Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer. Eydmann, M.E., Knowles, M.A. Cancer Genet. Cytogenet. (1997) [Pubmed]
  4. Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. Jones, T.A., Barker, H.M., da Cruz e Silva, E.F., Mayer-Jaekel, R.E., Hemmings, B.A., Spurr, N.K., Sheer, D., Cohen, P.T. Cytogenet. Cell Genet. (1993) [Pubmed]
  5. Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2A{alpha}. Bonness, K., Aragon, I.V., Rutland, B., Ofori-Acquah, S., Dean, N.M., Honkanen, R.E. Mol. Cancer Ther. (2006) [Pubmed]
 
WikiGenes - Universities