The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PPP2R3A  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: PP2A subunit B isoform PR72/PR130, PP2A subunit B isoform R3 isoform, PP2A subunit B isoforms B''-PR72/PR130, PP2A subunit B isoforms B72/B130, PPP2R3, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PPP2R3A

  • Moreover, PR72 is required during early embryonic development to regulate cell morphogenetic movements during body axis formation [1].
  • We find that PR130 modulates Wnt signal transduction by restricting the ability of Naked cuticle to function as a Wnt inhibitor [2].
  • We have further evaluated the effects of Ca(2+) on subunit composition, subcellular targeting, catalytic activity, and function during the cell cycle of a PR72-containing PP2A trimer (PP2A(T72)) by site-directed mutagenesis of either or both motifs [3].
  • From brain we isolated cDNA clones spanning an open reading frame encoding a 130-kDa protein (termed PR130) [4].
  • Amino acid sequence data of the 72-kDa regulatory subunit (termed PR72) were used to isolate cDNAs from human heart and fetal brain libraries and libraries derived from WI-38 and MCF-7 cells [4].
 

Biological context of PPP2R3A

 

Physical interactions of PPP2R3A

  • The G90D alteration inhibited the interaction of Abeta with the B56gamma subunit but had no effect on binding to the PR72 subunit [7].
 

Analytical, diagnostic and therapeutic context of PPP2R3A

  • Our data provide evidence that the inhibitory effect of Naked cuticle on Wnt signaling depends on the presence of PR72, both in mammalian cell culture and in Xenopus embryos [1].
  • Sequence alignment of these A subunit binding domains (ASBD) identified conserved residues in B/B55 and PR72 family members [8].

References

  1. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Creyghton, M.P., Roël, G., Eichhorn, P.J., Hijmans, E.M., Maurer, I., Destrée, O., Bernards, R. Genes Dev. (2005) [Pubmed]
  2. PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Creyghton, M.P., Roël, G., Eichhorn, P.J., Vredeveld, L.C., Destrée, O., Bernards, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A. Janssens, V., Jordens, J., Stevens, I., Van Hoof, C., Martens, E., De Smedt, H., Engelborghs, Y., Waelkens, E., Goris, J. J. Biol. Chem. (2003) [Pubmed]
  4. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. Hendrix, P., Mayer-Jackel, R.E., Cron, P., Goris, J., Hofsteenge, J., Merlevede, W., Hemmings, B.A. J. Biol. Chem. (1993) [Pubmed]
  5. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. Stevens, I., Janssens, V., Martens, E., Dilworth, S., Goris, J., Van Hoof, C. Eur. J. Biochem. (2003) [Pubmed]
  6. Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin. Tanabe, O., Hirata, D., Usui, H., Nishito, Y., Miyakawa, T., Igarashi, K., Takeda, M. Genes Cells (2001) [Pubmed]
  7. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. Esplin, E.D., Ramos, P., Martinez, B., Tomlinson, G.E., Mumby, M.C., Evans, G.A. Genes Chromosomes Cancer (2006) [Pubmed]
  8. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Li, X., Virshup, D.M. Eur. J. Biochem. (2002) [Pubmed]
 
WikiGenes - Universities