Gene Review:
FBXW7 - F-box and WD repeat domain containing 7,...
Homo sapiens
Synonyms:
AGO, Archipelago homolog, CDC4, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, ...
- BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Calhoun, E.S., Jones, J.B., Ashfaq, R., Adsay, V., Baker, S.J., Valentine, V., Hempen, P.M., Hilgers, W., Yeo, C.J., Hruban, R.H., Kern, S.E. Am. J. Pathol. (2003)
- Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Strohmaier, H., Spruck, C.H., Kaiser, P., Won, K.A., Sangfelt, O., Reed, S.I. Nature (2001)
- hCDC4 gene mutations in endometrial cancer. Spruck, C.H., Strohmaier, H., Sangfelt, O., Müller, H.M., Hubalek, M., Müller-Holzner, E., Marth, C., Widschwendter, M., Reed, S.I. Cancer Res. (2002)
- Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer. Kwak, E.L., Moberg, K.H., Wahrer, D.C., Quinn, J.E., Gilmore, P.M., Graham, C.A., Hariharan, I.K., Harkin, D.P., Haber, D.A., Bell, D.W. Gynecol. Oncol. (2005)
- The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Welcker, M., Orian, A., Jin, J., Grim, J.E., Grim, J.A., Harper, J.W., Eisenman, R.N., Clurman, B.E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. O'Neil, J., Grim, J., Strack, P., Rao, S., Tibbitts, D., Winter, C., Hardwick, J., Welcker, M., Meijerink, J.P., Pieters, R., Draetta, G., Sears, R., Clurman, B.E., Look, A.T. J. Exp. Med. (2007)
- Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Orlicky, S., Tang, X., Willems, A., Tyers, M., Sicheri, F. Cell (2003)
- Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., Nakayama, K.I. EMBO J. (2004)
- A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Rottmann, S., Wang, Y., Nasoff, M., Deveraux, Q.L., Quon, K.C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Jäger, S., Schwartz, H.T., Horvitz, H.R., Conradt, B. Proc. Natl. Acad. Sci. U.S.A. (2004)
- CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. Kemp, Z., Rowan, A., Chambers, W., Wortham, N., Halford, S., Sieber, O., Mortensen, N., von Herbay, A., Gunther, T., Ilyas, M., Tomlinson, I. Cancer Res. (2005)
- Changes in natural immunity during the course of HIV-1 infection. Brenner, B.G., Gryllis, C., Gornitsky, M., Wainberg, M.A. Clin. Exp. Immunol. (1993)
- FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Balamurugan, K., Sharan, S., Klarmann, K.D., Zhang, Y., Coppola, V., Summers, G.H., Roger, T., Morrison, D.K., Keller, J.R., Sterneck, E. Nat. Commun. (2013)
- Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Mao, J.H., Perez-Losada, J., Wu, D., Delrosario, R., Tsunematsu, R., Nakayama, K.I., Brown, K., Bryson, S., Balmain, A. Nature (2004)
- Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. Gupta-Rossi, N., Le Bail, O., Gonen, H., Brou, C., Logeat, F., Six, E., Ciechanover, A., Israël, A. J. Biol. Chem. (2001)
- Cyclin E dysregulation and chromosomal instability in endometrial cancer. Hubalek, M.M., Widschwendter, A., Erdel, M., Gschwendtner, A., Fiegl, H.M., Müller, H.M., Goebel, G., Mueller-Holzner, E., Marth, C., Spruck, C.H., Reed, S.I., Widschwendter, M. Oncogene (2004)
- Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer. Ekholm-Reed, S., Spruck, C.H., Sangfelt, O., van Drogen, F., Mueller-Holzner, E., Widschwendter, M., Zetterberg, A., Reed, S.I., Reed, S.E. Cancer Res. (2004)
- Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism. Nowak, D., Mossner, M., Baldus, C.D., Hopfer, O., Thiel, E., Hofmann, W.K. International journal of medical sciences (2006)
- CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer. Koh, M.S., Ittmann, M., Kadmon, D., Thompson, T.C., Leach, F.S. Cancer Biol. Ther. (2006)
- Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Tetzlaff, M.T., Yu, W., Li, M., Zhang, P., Finegold, M., Mahon, K., Harper, J.W., Schwartz, R.J., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. Ye, X., Nalepa, G., Welcker, M., Kessler, B.M., Spooner, E., Qin, J., Elledge, S.J., Clurman, B.E., Harper, J.W. J. Biol. Chem. (2004)
- The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Wei, W., Jin, J., Schlisio, S., Harper, J.W., Kaelin, W.G. Cancer Cell (2005)
- SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Wu, G., Lyapina, S., Das, I., Li, J., Gurney, M., Pauley, A., Chui, I., Deshaies, R.J., Kitajewski, J. Mol. Cell. Biol. (2001)
- Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Sundqvist, A., Bengoechea-Alonso, M.T., Ye, X., Lukiyanchuk, V., Jin, J., Harper, J.W., Ericsson, J. Cell metabolism. (2005)
- Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. Gustafson, M.P., Welcker, M., Hwang, H.C., Clurman, B.E. Biochem. Biophys. Res. Commun. (2005)
- Inactivation of hCDC4 can cause chromosomal instability. Rajagopalan, H., Jallepalli, P.V., Rago, C., Velculescu, V.E., Kinzler, K.W., Vogelstein, B., Lengauer, C. Nature (2004)
- The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis. Balamurugan, K., Wang, J.M., Tsai, H.H., Sharan, S., Anver, M., Leighty, R., Sterneck, E. EMBO. J. (2010)
- TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability. Sim, K.G., Zang, Z., Yang, C.M., Bonventre, J.V., Hsu, S.I. Cell Cycle (2004)
- Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. Cassia, R., Moreno-Bueno, G., Rodríguez-Perales, S., Hardisson, D., Cigudosa, J.C., Palacios, J. J. Pathol. (2003)
- Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin. Wu, G., Hubbard, E.J., Kitajewski, J.K., Greenwald, I. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. Williams, R.D., Al-Saadi, R., Chagtai, T., Popov, S., Messahel, B., Sebire, N., Gessler, M., Wegert, J., Graf, N., Leuschner, I., Hubank, M., Jones, C., Vujanic, G., Pritchard-Jones, K. Clin. Cancer Res. (2010)
- sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Hubbard, E.J., Wu, G., Kitajewski, J., Greenwald, I. Genes Dev. (1997)
- Identification of and pattern of transitions of cardiac, adult slow and slow skeletal muscle-like embryonic isoforms of troponin T in developing rat and human skeletal muscles. Sabry, M.A., Dhoot, G.K. J. Muscle Res. Cell. Motil. (1991)
- Serological investigation of HIV-1 variant subtype strains in transmission in Nairobi. Songok, E.M., Tukei, P.M., Mulaa, F.J. East African medical journal. (1996)