High impact information on PPP3R2

• RWD exhibited greater homology to a group of receptor for activated C-kinase (RACK), a product of auxin-regulated gene from cultured cells (arcA) and a Chlamydomonas beta subunit-like polypeptide (Cblp) rather than to the beta subunits of heterotrimeric G protein complexes [1].
• Northern blots showed that transcripts for CBLP are specifically and highly expressed in the testis [2].
• The overall predicted amino acid sequence homology between CBLP and calcineurin B is 82% [2].
• A cDNA clone encoding a novel calcineurin B-like protein (CBLP) was isolated from a rat testis cDNA library by cross-hybridization with a calcineurin B cDNA probe [2].
• PPP3R has two isoforms, PPP3R1 (also known as PP2Bbeta1) and PPP3R2 (also known as PP2BB2) [3].

Biological context of PPP3R2

• PPP3RL gene was predicated to encode 171 amino acid residues with four EF-hand calcium-binding domains and this putative protein shares 82.9% and 80.5% identity with PPP3R2 of rat and mouse, respectively [3].
• A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger [4].

Anatomical context of PPP3R2

• While PPP3R1 is ubiquitously expressed in different tissues, PPP3R2 is exclusively expressed in testis [3].
• CONCLUSION: Anterior decompression and internal fixation with CBLP proves to be effective for managing cervical intervertebral disc herniation [5].

Analytical, diagnostic and therapeutic context of PPP3R2

• The patients received anterior decompression, autogenous iliac bone grafting and internal fixation with CBLP, and follow-up studies lasting for 12 to 24 months (mean 18 months) were conducted in all the cases [5].

References