The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TNFRSF19  -  tumor necrosis factor receptor superfamily...

Homo sapiens

Synonyms: TAJ, TAJ-alpha, TRADE, TROY, Toxicity and JNK inducer, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TNFRSF19

  • The significance of these studies takes on added importance with the recent discovery that the level of free KDN is elevated in human fetal cord but not matched adult red blood cells and in ovarian cancer cells (Inoue, S., Lin, S-L., Chang, T., Wu, S-H., Yao, C-W., Chu, T-Y., Troy, F [1].
  • Increased incidence of life-threatening ventricular arrhythmias in implantable defibrillator patients after the World Trade Center attack [2].
  • The absence of rhabdomyolysis-induced renal failure following the World Trade Center collapse [3].
  • We report a sentinel case of acute eosinophilic pneumonia in a firefighter exposed to high concentrations of World Trade Center dust during the rescue effort from September 11 to 24 [4].
  • However, TROY had never been associated with melanoma, and it was selected for further study [5].
 

Psychiatry related information on TNFRSF19

 

High impact information on TNFRSF19

  • Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system [11].
  • In vitro exogenously added TAJ reversed neurite outgrowth caused by MAIFs [12].
  • As part of the General Agreement on Trade in Services (GATS) negotiations, the WTO working party on reform of domestic regulation is developing a regulatory reform agenda which could mark a new era of compulsion in international trade law [13].
  • The strongly decreased number of hair follicles observed in c(IkappaBalphaDeltaN) mice compared with tabby mice, indicates that additional signals, such as TROY, must regulate NF-kappaB activity in specific hair follicle subtypes [14].
  • Interestingly, in situ hybridization analysis of the embryo showed that TROY mRNA was exclusively expressed in the epithelium of many tissues [15].
 

Chemical compound and disease context of TNFRSF19

  • OBJECTIVE: The purpose of this study was to report on the relationship between maternal PTSD symptoms and salivary cortisol levels in infants of mothers directly exposed to the World Trade Center collapse on September 11, 2001 during pregnancy [6].
  • Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target [5].
  • Individuals needing intensive mental health treatment continued to enter Project Liberty for two years after the World Trade Center attacks [16].
  • Maimonides Medical Center, whose pharmacists responded to the medical and pharmaceutical needs of victims of the World Trade Center attacks and anthrax exposures, has developed the PERT, modeled after the Health Emergency Incident Command System, to standardize the response of their pharmacists in the event of such an attack [17].
  • Sex Trade, Sexual Risk, and Nondisclosure of HIV Serostatus: Findings from HIV-Infected Persons with a History of Alcohol Problems [18].
 

Biological context of TNFRSF19

  • By searching the expressed sequence tag database, a novel murine tumor necrosis factor receptor designated TNFRSF19 was identified [19].
  • We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development [20].
  • Although it lacks a death domain, TAJ is capable of inducing apoptosis by a caspase-independent mechanism [20].
  • TAJ possesses a unique cytoplasmic domain with no sequence homology to the previously characterized members of the TNFR family [20].
  • These probes were developed for the detection of polysialic acid on neural cell adhesion molecules (Troy, F [21].
 

Anatomical context of TNFRSF19

 

Associations of TNFRSF19 with chemical compounds

  • The Elusive Mechanism of Olefin Metathesis Promoted by (NHC)Ru-Based Catalysts: A Trade between Steric, Electronic, and Solvent Effects [24].
  • Characteristically, cell death triggered by TAJ/TROY was accompanied by phosphatidylserine externalization, loss of the mitochondrial transmembrane potential and independent of caspase activation [23].
  • With the optimization of the trapping efficiency, we detected 391 nmol of ROS/cigarette in the mainstream CS for a standard cigarette 2R4F under standard Federal Trade Commission smoking protocol [25].
  • This study examined the effects of cigarette yield (Federal Trade Commission-determined deliveries of nicotine, tar and CO) on both biological exposure to smoke constituents and smoking behaviors [26].
  • In the four months following the 11 September 2001 attacks on the World Trade Center, nearly 350,000 people signed up for Disaster Relief Medicaid. The process was quick and simple; applicants completed a one-page form and got a decision on the spot or the next day [27].
 

Other interactions of TNFRSF19

 

Analytical, diagnostic and therapeutic context of TNFRSF19

  • Taken together with the data that the TNFRSF19 extracellular domain-immunoglobulin fusion protein did not affect the allogeneic mixed lymphocyte reaction, our data indicate that TNFRSF19 is not involved in the modulation of immune responses [19].
  • The World Trade Center attack: increased frequency of defibrillator shocks for ventricular arrhythmias in patients living remotely from New York City [32].
  • OBJECTIVES: To quantify respiratory health effects of World Trade Center exposure in the New York City Fire Department. MEASUREMENTS: Longitudinal study of pulmonary function in 12,079 New York City Fire Department rescue workers employed on or before 09/11/2001 [28].
  • Between 01/01/1997 and 09/11/2002, 31,994 spirometries were obtained and the FEV(1) and FVC were analyzed for differences according to estimated World Trade Center exposure intensity [28].
  • World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells [4].

References

  1. Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis. Angata, T., Nakata, D., Matsuda, T., Kitajima, K., Troy, F.A. J. Biol. Chem. (1999) [Pubmed]
  2. Increased incidence of life-threatening ventricular arrhythmias in implantable defibrillator patients after the World Trade Center attack. Steinberg, J.S., Arshad, A., Kowalski, M., Kukar, A., Suma, V., Vloka, M., Ehlert, F., Herweg, B., Donnelly, J., Philip, J., Reed, G., Rozanski, A. J. Am. Coll. Cardiol. (2004) [Pubmed]
  3. The absence of rhabdomyolysis-induced renal failure following the World Trade Center collapse. Goldfarb, D.S., Chung, S. Am. J. Med. (2002) [Pubmed]
  4. Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust. Rom, W.N., Weiden, M., Garcia, R., Yie, T.A., Vathesatogkit, P., Tse, D.B., McGuinness, G., Roggli, V., Prezant, D. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  5. Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target. Spanjaard, R.A., Whren, K.M., Graves, C., Bhawan, J. Int. J. Cancer (2007) [Pubmed]
  6. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. Yehuda, R., Engel, S.M., Brand, S.R., Seckl, J., Marcus, S.M., Berkowitz, G.S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  7. Implications of the World Trade Center attack for the public health and health care infrastructures. Klitzman, S., Freudenberg, N. American journal of public health. (2003) [Pubmed]
  8. A propensity score analysis of brief worksite crisis interventions after the World Trade Center disaster: implications for intervention and research. Boscarino, J.A., Adams, R.E., Foa, E.B., Landrigan, P.J. Medical care. (2006) [Pubmed]
  9. Attachment and psychological adaptation in high exposure survivors of the September 11th attack on the World Trade Center. Fraley, R.C., Fazzari, D.A., Bonanno, G.A., Dekel, S. Personality and social psychology bulletin. (2006) [Pubmed]
  10. Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). Cabrero, E., Gómez-Acebo, A., García-Alcázar, I., Luna, J.D., Luna, A. La Medicina del lavoro. (2003) [Pubmed]
  11. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Park, J.B., Yiu, G., Kaneko, S., Wang, J., Chang, J., He, X.L., Garcia, K.C., He, Z. Neuron (2005) [Pubmed]
  12. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Shao, Z., Browning, J.L., Lee, X., Scott, M.L., Shulga-Morskaya, S., Allaire, N., Thill, G., Levesque, M., Sah, D., McCoy, J.M., Murray, B., Jung, V., Pepinsky, R.B., Mi, S. Neuron (2005) [Pubmed]
  13. Rewriting the regulations: how the World Trade Organisation could accelerate privatisation in health-care systems. Pollock, A.M., Price, D. Lancet (2000) [Pubmed]
  14. NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Schmidt-Ullrich, R., Tobin, D.J., Lenhard, D., Schneider, P., Paus, R., Scheidereit, C. Development (2006) [Pubmed]
  15. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. Kojima, T., Morikawa, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Senba, E., Kitamura, T. J. Biol. Chem. (2000) [Pubmed]
  16. Characteristics of project liberty clients that predicted referrals to intensive mental health services. Covell, N.H., Essock, S.M., Felton, C.J., Donahue, S.A. Psychiatric services (Washington, D.C.) (2006) [Pubmed]
  17. Organization of a health-system pharmacy team to respond to episodes of terrorism. Cohen, V. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. (2003) [Pubmed]
  18. Sex Trade, Sexual Risk, and Nondisclosure of HIV Serostatus: Findings from HIV-Infected Persons with a History of Alcohol Problems. Raj, A., Cheng, D.M., Levison, R., Meli, S., Samet, J.H. AIDS and behavior. (2006) [Pubmed]
  19. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Hu, S., Tamada, K., Ni, J., Vincenz, C., Chen, L. Genomics (1999) [Pubmed]
  20. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. Eby, M.T., Jasmin, A., Kumar, A., Sharma, K., Chaudhary, P.M. J. Biol. Chem. (2000) [Pubmed]
  21. Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells. Livingston, B.D., Jacobs, J.L., Glick, M.C., Troy, F.A. J. Biol. Chem. (1988) [Pubmed]
  22. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Satoh, J., Tabunoki, H., Yamamura, T., Arima, K., Konno, H. Neuropathol. Appl. Neurobiol. (2007) [Pubmed]
  23. An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. Wang, Y., Li, X., Wang, L., Ding, P., Zhang, Y., Han, W., Ma, D. J. Cell. Sci. (2004) [Pubmed]
  24. The Elusive Mechanism of Olefin Metathesis Promoted by (NHC)Ru-Based Catalysts: A Trade between Steric, Electronic, and Solvent Effects. Correa, A., Cavallo, L. J. Am. Chem. Soc. (2006) [Pubmed]
  25. Fluorescent approach to quantitation of reactive oxygen species in mainstream cigarette smoke. Ou, B., Huang, D. Anal. Chem. (2006) [Pubmed]
  26. Cigarette brand-switching: effects on smoke exposure and smoking behavior. Zacny, J.P., Stitzer, M.L. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  27. Radical simplification: Disaster Relief Medicaid in New York City. Haslanger, K. Health affairs (Project Hope) (2003) [Pubmed]
  28. Pulmonary function after exposure to the World Trade Center collapse in the New York City Fire Department. Banauch, G.I., Hall, C., Weiden, M., Cohen, H.W., Aldrich, T.K., Christodoulou, V., Arcentales, N., Kelly, K.J., Prezant, D.J. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  29. Quality of life, nutritional status, and gastrointestinal hormone profile following the Whipple procedure. McLeod, R.S., Taylor, B.R., O'Connor, B.I., Greenberg, G.R., Jeejeebhoy, K.N., Royall, D., Langer, B. Am. J. Surg. (1995) [Pubmed]
  30. Seattle, the World Trade Organization and the NHS. McKee, M., Mossialos, E. Journal of the Royal Society of Medicine. (2000) [Pubmed]
  31. An evaluation of recent population scenarios for the EEA and Switzerland. Cruijsen, H., Eding, H. Maandstatistiek van de bevolking (Hague, Netherlands : 1982) (1996) [Pubmed]
  32. The World Trade Center attack: increased frequency of defibrillator shocks for ventricular arrhythmias in patients living remotely from New York City. Shedd, O.L., Sears, S.F., Harvill, J.L., Arshad, A., Conti, J.B., Steinberg, J.S., Curtis, A.B. J. Am. Coll. Cardiol. (2004) [Pubmed]
 
WikiGenes - Universities