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SMPD3  -  sphingomyelin phosphodiesterase 3, neutral...

Homo sapiens

Synonyms: NSMASE2, Neutral sphingomyelinase 2, Neutral sphingomyelinase II, Sphingomyelin phosphodiesterase 3, nSMase-2, ...
 
 
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High impact information on SMPD3

  • Our knowledge of SMPD3 function is consistent with the pathology observed in mutant mice and provides new insight into human pathologies [1].
  • Our studies suggest that SMPD3 is segregated into detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons, where its transient activation modifies the lipid bilayer, an essential step in the Golgi secretory pathway [2].
  • In this study, nSMase2 was found to translocate acutely to the plasma membrane of A549 epithelial cells in response to tumor necrosis factor alpha (TNF-alpha) in a time- and dose-dependent manner [3].
  • However, there is little information on the physiological regulation and roles of the cloned N-SMase enzyme, nSMase2 [3].
  • The neutral sphingomyelinases (nSMases) are considered major candidates for mediating the stress-induced production of ceramide. nSMase2, which has two hydrophobic segments near the NH(2)-terminal region, has been reported to be located at the plasma membrane and play important roles in ceramide-mediated signaling [4].
 

Biological context of SMPD3

 

Anatomical context of SMPD3

 

Associations of SMPD3 with chemical compounds

References

  1. A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Aubin, I., Adams, C.P., Opsahl, S., Septier, D., Bishop, C.E., Auge, N., Salvayre, R., Negre-Salvayre, A., Goldberg, M., Guénet, J.L., Poirier, C. Nat. Genet. (2005) [Pubmed]
  2. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Stoffel, W., Jenke, B., Blöck, B., Zumbansen, M., Koebke, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor {alpha}-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells: p38 MAPK IS AN UPSTREAM REGULATOR OF nSMase2. Clarke, C.J., Truong, T.G., Hannun, Y.A. J. Biol. Chem. (2007) [Pubmed]
  4. Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues: ROLE OF PALMITOYLATION IN SUBCELLULAR LOCALIZATION. Tani, M., Hannun, Y.A. J. Biol. Chem. (2007) [Pubmed]
  5. nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Levy, M., Castillo, S.S., Goldkorn, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. De Palma, C., Meacci, E., Perrotta, C., Bruni, P., Clementi, E. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  7. Analysis of membrane topology of neutral sphingomyelinase 2. Tani, M., Hannun, Y.A. FEBS Lett. (2007) [Pubmed]
 
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