Gene Review:
SMPD3 - sphingomyelin phosphodiesterase 3, neutral...
Homo sapiens
Synonyms:
NSMASE2, Neutral sphingomyelinase 2, Neutral sphingomyelinase II, Sphingomyelin phosphodiesterase 3, nSMase-2, ...
- A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Aubin, I., Adams, C.P., Opsahl, S., Septier, D., Bishop, C.E., Auge, N., Salvayre, R., Negre-Salvayre, A., Goldberg, M., Guénet, J.L., Poirier, C. Nat. Genet. (2005)
- Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Stoffel, W., Jenke, B., Blöck, B., Zumbansen, M., Koebke, J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor {alpha}-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells: p38 MAPK IS AN UPSTREAM REGULATOR OF nSMase2. Clarke, C.J., Truong, T.G., Hannun, Y.A. J. Biol. Chem. (2007)
- Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues: ROLE OF PALMITOYLATION IN SUBCELLULAR LOCALIZATION. Tani, M., Hannun, Y.A. J. Biol. Chem. (2007)
- nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Levy, M., Castillo, S.S., Goldkorn, T. Biochem. Biophys. Res. Commun. (2006)
- Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. De Palma, C., Meacci, E., Perrotta, C., Bruni, P., Clementi, E. Arterioscler. Thromb. Vasc. Biol. (2006)
- Analysis of membrane topology of neutral sphingomyelinase 2. Tani, M., Hannun, Y.A. FEBS Lett. (2007)