Gene Review:
HIF1AN - hypoxia inducible factor 1, alpha subunit...
Homo sapiens
Synonyms:
DKFZp762F1811, FIH-1, FIH1, FLJ20615, FLJ22027, ...
- Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. Linke, S., Stojkoski, C., Kewley, R.J., Booker, G.W., Whitelaw, M.L., Peet, D.J. J. Biol. Chem. (2004)
- Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. Morris, M.R., Maina, E., Morgan, N.V., Gentle, D., Astuti, D., Moch, H., Kishida, T., Yao, M., Schraml, P., Richards, F.M., Latif, F., Maher, E.R. J. Clin. Pathol. (2004)
- Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line. Ke, Q., Kluz, T., Costa, M. International journal of environmental research and public health [electronic resource]. (2005)
- Proline hydroxylation and gene expression. Kaelin, W.G. Annu. Rev. Biochem. (2005)
- FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Mahon, P.C., Hirota, K., Semenza, G.L. Genes Dev. (2001)
- Posttranslational hydroxylation of ankyrin repeats in I{kappa}B proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Cockman, M.E., Lancaster, D.E., Stolze, I.P., Hewitson, K.S., McDonough, M.A., Coleman, M.L., Coles, C.H., Yu, X., Hay, R.T., Ley, S.C., Pugh, C.W., Oldham, N.J., Masson, N., Schofield, C.J., Ratcliffe, P.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Dann, C.E., Bruick, R.K., Deisenhofer, J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. Hewitson, K.S., McNeill, L.A., Riordan, M.V., Tian, Y.M., Bullock, A.N., Welford, R.W., Elkins, J.M., Oldham, N.J., Bhattacharya, S., Gleadle, J.M., Ratcliffe, P.J., Pugh, C.W., Schofield, C.J. J. Biol. Chem. (2002)
- Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1. Yeo, E.J., Ryu, J.H., Cho, Y.S., Chun, Y.S., Huang, L.E., Kim, M.S., Park, J.W. Blood (2006)
- Regulation of HIF: asparaginyl hydroxylation. Peet, D., Linke, S. Novartis Found. Symp. (2006)
- Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K.I., Myllyharju, J. J. Biol. Chem. (2004)
- Clioquinol, a Cu(II)/Zn(II) Chelator, Inhibits Both Ubiquitination and Asparagine Hydroxylation of Hypoxia-inducible Factor-1{alpha}, Leading to Expression of Vascular Endothelial Growth Factor and Erythropoietin in Normoxic Cells. Choi, S.M., Choi, K.O., Park, Y.K., Cho, H., Yang, E.G., Park, H. J. Biol. Chem. (2006)
- Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. Lee, C., Kim, S.J., Jeong, D.G., Lee, S.M., Ryu, S.E. J. Biol. Chem. (2003)
- Siah-1 facilitates ubiquitination and degradation of factor inhibiting HIF-1alpha (FIH). Fukuba, H., Yamashita, H., Nagano, Y., Jin, H.G., Hiji, M., Ohtsuki, T., Takahashi, T., Kohriyama, T., Matsumoto, M. Biochem. Biophys. Res. Commun. (2007)
- The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells. Choi, S.M., Choi, K.O., Lee, N., Oh, M., Park, H. Biochem. Biophys. Res. Commun. (2006)
- Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Soilleux, E.J., Turley, H., Tian, Y.M., Pugh, C.W., Gatter, K.C., Harris, A.L. Histopathology (2005)
- Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J.H., Stolze, I., Klinger, M., Huang, W.Q., Wotzlaw, C., Hellwig-Bürgel, T., Jelkmann, W., Acker, H., Fandrey, J. J. Cell. Sci. (2003)