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PRKCI  -  protein kinase C, iota

Homo sapiens

Synonyms: Atypical protein kinase C-lambda/iota, DXS1179E, PKCI, PRKC-lambda/iota, Protein kinase C iota type, ...
 
 
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High impact information on PRKCI

  • PKCI by itself, although localized in the cytosol and nucleus of the cells, has no known physiological function and did not demonstrate transcriptional activity [1].
  • Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3 [2].
  • The sequence information derived from genomic DNA and from both clones was identical and showed a high degree of homology to human PRKCI (HSAXq21.3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology) [3].
  • The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3 [3].
 

Analytical, diagnostic and therapeutic context of PRKCI

  • Two bovine BAC clones were identified by PCR as containing the bovine gene PRKCI [3].

References

  1. Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells. Razin, E., Zhang, Z.C., Nechushtan, H., Frenkel, S., Lee, Y.N., Arudchandran, R., Rivera, J. J. Biol. Chem. (1999) [Pubmed]
  2. Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. Mazzarella, R., Ciccodicola, A., Esposito, T., Arcucci, A., Migliaccio, C., Jones, C., Schlessinger, D., D'Urso, M., D'Esposito, M. Genomics (1995) [Pubmed]
  3. The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3. De Donato, M., Gallagher, D.S., Davis, S.K., Stelly, D.M., Taylor, J.F. Cytogenet. Cell Genet. (2001) [Pubmed]
 
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