The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Dclre1a  -  DNA cross-link repair 1A, PSO2 homolog (S....

Mus musculus

Synonyms: 2810043H12Rik, AU022226, DNA cross-link repair 1A protein, Kiaa0086, Pso2, ...
 
 
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Dclre1a

  • Crossing of Snm1 mutant mice with a Trp53 null mutant resulted in an increase in mortality and a restriction of the tumor type to lymphomas, particularly those of the thymus [1].
 

High impact information on Dclre1a

  • Here, we report on the phenotype of a knockout of Snm1 in the mouse [1].
  • In particular, mammalian SNM1 has been shown to be required in a mitotic checkpoint that causes arrest of cells in prophase prior to chromosome condensation in response to spindle poisons [1].
  • The eukaryotic SNM1 gene family has been implicated in a number of cellular pathways, including repair of DNA interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, and participation in cell cycle checkpoint pathways [1].

References

  1. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Ahkter, S., Richie, C.T., Zhang, N., Behringer, R.R., Zhu, C., Legerski, R.J. Mol. Cell. Biol. (2005) [Pubmed]
 
WikiGenes - Universities