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YLPM1  -  YLP motif containing 1

Homo sapiens

Synonyms: C14orf170, Nuclear protein ZAP3, PPP1R169, YLP motif-containing protein 1, ZAP, ...
 
 
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Disease relevance of YLPM1

  • Zinc-finger antiviral protein (ZAP) is a host antiviral factor that specifically inhibits the replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing accumulation of the viral mRNA in the cytoplasm [1].
  • The FL14676485 cDNA clone was isolated from a 43(HIV) lambda ZAP Escherichia coli expression library and screened with a panel of rabbit and mouse anti-apoptotic Abs [2].
  • The gene encoding the structural subunit of PCFO20 fimbriae, fotA, was cloned from strain ARG-2 in the expression phage vector lambda ZAP Express [3].
  • We have isolated a 4.3-kb cDNA encoding the human AspH (hAspH) by immunoscreening of a human osteosarcoma (MG63) cDNA library in lambda ZAP with an antiserum raised against membrane fractions of these cells [4].
  • 5. After 50 ml ZAP IV the PVR change with hypoxia was only from 3.6 +/- 0.6 to 3.9 +/- 0 [5].
 

High impact information on YLPM1

 

Chemical compound and disease context of YLPM1

  • In a further 5 dogs pretreated with meclofenamate (2 mg/kg IV) the PVR increased from 3.7 +/- 0.4 to 7.5 +/- 0.4 with hypoxia prior to IV ZAP and from 4.4 +/- 0.5 to 6.5 +/- 0.6 after ZAP [5].
 

Biological context of YLPM1

  • The N-terminal amino acid sequences of tryptic fragments of protein L were determined, and on the basis of these sequence data, oligonucleotides were synthesized and used to screen a genomic library of peptostreptococcal DNA in the lambda ZAP vector [9].
  • Using an M. bovis pilin gene as a hybridization probe to screen a lambda ZAP library of M. lacunata DNA, we have isolated a clone that not only contains the entire type 4 pilin gene inversion region of M. lacunata but inverts the 2-kb region on a plasmid subclone (pMxL1) in Escherichia coli [10].
  • Polymorphonuclear neutrophils (PMNs) were isolated from human blood, and PMN phagocytosis was assessed by measuring the chemiluminescence (CL) response in the presence of ZAP (opsonized zymosin particles containing luminol) [11].
  • Prior to ZAP, hypoxia (F1O2 12%) in 5 anesthetized dogs increased pulmonary vascular resistance (PVR: mm Hg/L/min) from 3.7 +/- 0.8 to 7.1 +/- 1 [5].
 

Anatomical context of YLPM1

  • A clone representing ECP mRNA was isolated from an eosinophil lambda ZAP cDNA library [12].
  • A cDNA (designated hGSTYBX) encompassing the complete coding sequence of a hamster mu-class glutathione S-transferase (GST) subunit was cloned from a lambda ZAP library constructed with mRNA isolated from triamcinolone acetonide-treated smooth muscle tumor cells (DDT1 MF-2) [13].
  • A human hippocampus cDNA library in lambda ZAP II was screened by hybridization with a rat brain inositol 1,4,5-trisphosphate (InsP3) 3-kinase cDNA [14].
  • In vitro, incubation of CA membranes with plasma led to less C3 conversion (20% vs. 40%), less PMN aggregating activity (5.9 ZAP units vs. 36.3) and less decrement in CH50 (6.5% vs. 22%) than like incubations of Cu [15].
  • PMNL did not migrate through a fibroblast monolayer unless a chemotactic factor, e.g. C5a, interleukin-8 (IL-8) or zymosan-activated plasma (ZAP; C5adesArg), was added [16].
 

Associations of YLPM1 with chemical compounds

  • Using the C3-like sequence as a probe, two overlapping cDNA clones were isolated from the lambda ZAP library, which together covered the entire region encoding the putative lamprey pro-C3 [17].
  • Histologically, pretreatment with pranlukast or MK-886 did not affect the ZAP-induced PMN infiltration [18].
  • Neither the antihistaminic agent diphenhydramine, nor the bradykinin B2 receptor antagonist, HOE140, affected the ZAP-induced, late-phase extravasation [18].
  • An embryonic (8-10 weeks gestation) heart lambda ZAP Express cDNA library was screened with an oligonucleotide probe deduced from a consensus amino acid sequence which is highly conserved for Zn2+-finger proteins, and approximately 350 positive clones were isolated from 1 x 10(4) plaque-forming units (pfu) initially plated [19].
  • Current clamp analysis demonstrated that voltage-dependent membrane resonance in response to a ZAP input current at depolarized holding potentials (approximately -50 mV) was specifically suppressed by forskolin or 5-HT [20].
 

Analytical, diagnostic and therapeutic context of YLPM1

  • Immunoprecipitation of ZAP coprecipitated the exosome components [1].
  • 4. Trafficking of (111)In-eosinophils to skin sites injected with PAF, ZAP or antigen in sensitized sites was inhibited by oral administration of all PDE4 inhibitors [21].
  • METHODS: Ten physicians with varying endoscopy experience were presented with 15 endoscopic photographs of the Z-line and were asked to classify them according to the ZAP classification [22].
  • By Western blot we showed a parallel recruitment of the PTK p70-ZAP in this vesicles [23].
  • SDS-PAGE analysis found at least 7 protein components in the zymogen granule membranes including ZAP (zymogen granule membrane associated protein) 75, 54, 47, 36, 32, 29, 25 (numbers refer to their apparent kDas) [24].

References

  1. The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Guo, X., Ma, J., Sun, J., Gao, G. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Induction of apoptosis by HIV-1-infected monocytic cells. Sperber, K., Beuria, P., Singha, N., Gelman, I., Cortes, P., Chen, H., Kraus, T. J. Immunol. (2003) [Pubmed]
  3. The structural gene encoding human enterotoxigenic Escherichia coli PCFO20 is homologous to that for porcine 987P. Viboud, G.I., Jonson, G., Dean-Nystrom, E., Svennerholm, A.M. Infect. Immun. (1996) [Pubmed]
  4. Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase. Korioth, F., Gieffers, C., Frey, J. Gene (1994) [Pubmed]
  5. Zymosan activation of plasma reduces hypoxic pulmonary vasoconstriction. Weir, E.K., Tierney, J.F., Chesler, E., Lundquist, L.J., Craddock, P.R. Respiration physiology. (1983) [Pubmed]
  6. RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells. Bacon, K.B., Szabo, M.C., Yssel, H., Bolen, J.B., Schall, T.J. J. Exp. Med. (1996) [Pubmed]
  7. Cloning and characterization of a second complementary DNA for human tryptase. Miller, J.S., Moxley, G., Schwartz, L.B. J. Clin. Invest. (1990) [Pubmed]
  8. Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. Volpp, B.D., Nauseef, W.M., Donelson, J.E., Moser, D.R., Clark, R.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. Protein L, a bacterial immunoglobulin-binding protein and possible virulence determinant. Kastern, W., Holst, E., Nielsen, E., Sjöbring, U., Björck, L. Infect. Immun. (1990) [Pubmed]
  10. Identification, cloning, and sequencing of piv, a new gene involved in inverting the pilin genes of Moraxella lacunata. Marrs, C.F., Rozsa, F.W., Hackel, M., Stevens, S.P., Glasgow, A.C. J. Bacteriol. (1990) [Pubmed]
  11. Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro. Jin, G.F., Guo, Y.S., Ball, C., Houston, C.W. Regul. Pept. (1993) [Pubmed]
  12. Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases. Barker, R.L., Loegering, D.A., Ten, R.M., Hamann, K.J., Pease, L.R., Gleich, G.J. J. Immunol. (1989) [Pubmed]
  13. Cloning of a mu-class glutathione S-transferase complementary DNA and characterization of its glucocorticoid inducibility in a smooth muscle tumor cell line. Norris, J.S., Schwartz, D.A., MacLeod, S.L., Fan, W.M., O'Brien, T.J., Harris, S.E., Trifiletti, R., Cornett, L.E., Cooper, T.M., Levi, W.M. Mol. Endocrinol. (1991) [Pubmed]
  14. Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. Takazawa, K., Perret, J., Dumont, J.E., Erneux, C. Biochem. J. (1991) [Pubmed]
  15. Symptoms and activation of granulocytes and complement with two dialysis membranes. Ivanovich, P., Chenoweth, D.E., Schmidt, R., Klinkmann, H., Boxer, L.A., Jacob, H.S., Hammerschmidt, D.E. Kidney Int. (1983) [Pubmed]
  16. Polymorphonuclear leucocyte migration through human dermal fibroblast monolayers is dependent on both beta 2-integrin (CD11/CD18) and beta 1-integrin (CD29) mechanisms. Gao, J.X., Issekutz, A.C. Immunology (1995) [Pubmed]
  17. Complete complementary DNA sequence of the third component of complement of lamprey. Implication for the evolution of thioester containing proteins. Nonaka, M., Takahashi, M. J. Immunol. (1992) [Pubmed]
  18. Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation. Tokita, K., Uchida, Y., Yamamoto, T. J. Leukoc. Biol. (2006) [Pubmed]
  19. Identification of genes encoding zinc finger motifs in the cardiovascular system. Wang, R., Hwang, D.M., Cukerman, E., Liew, C.C. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  20. Serotonergic modulation of persistent sodium currents and membrane excitability via cyclic AMP-protein kinase A cascade in mesencephalic V neurons. Tanaka, S., Chandler, S.H. J. Neurosci. Res. (2006) [Pubmed]
  21. A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Cooper, N., Teixeira, M.M., Warneck, J., Miotla, J.M., Wills, R.E., Macari, D.M., Gristwood, R.W., Hellewell, P.G. Br. J. Pharmacol. (1999) [Pubmed]
  22. Endoscopic assessment of the "Z-line" (squamocolumnar junction) appearance: reproducibility of the ZAP classification among endoscopists. Wallner, B., Sylvan, A., Janunger, K.G. Gastrointest. Endosc. (2002) [Pubmed]
  23. P56lck A lymphocyte specific protein tyrosine kinase: activation, regulation and signal transduction. Fischer, S., Marie-Cardine, A., Ramos-Morales, F., Bougeret, C., Soula, M., Maridonneau-Parini, I., Benarous, R. Cell. Mol. Biol. (Noisy-le-grand) (1994) [Pubmed]
  24. Analysis of ZAPs, zymogen granule membrane associated proteins, in the regulated exocytosis of the pancreas. Fukuoka, S. Biosci. Biotechnol. Biochem. (1994) [Pubmed]
 
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