Gene Review:
Foxo1 - forkhead box O1
Mus musculus
Synonyms:
AI876417, Afxh, FKHR, Fkhr, Fkhr1, ...
Yamashita,
Sone,
Lo,
Shimoda,
Young,
Burks,
Benito,
Furuyama,
White,
Smyth,
Sharma,
Valverde,
Fabregat,
Kitayama,
Falender,
Ikeda,
Kitayama,
Mur,
Nakayama,
Eckhoff,
Nishikawa,
Nakayama,
Contreras,
Furuyama,
Brownlee,
Mori,
Motoyama,
Valverde,
Thompson,
Richards,
Ogawa,
Mori,
Hisatsune,
Benito,
Bilbao,
Yoshida-Araki,
- Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. Hribal, M.L., Nakae, J., Kitamura, T., Shutter, J.R., Accili, D. J. Cell Biol. (2003)
- Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Tsai, W.C., Bhattacharyya, N., Han, L.Y., Hanover, J.A., Rechler, M.M. Endocrinology (2003)
- SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein {alpha} Transcriptional Complex. Qiao, L., Shao, J. J. Biol. Chem. (2006)
- Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Ni, Y.G., Berenji, K., Wang, N., Oh, M., Sachan, N., Dey, A., Cheng, J., Lu, G., Morris, D.J., Castrillon, D.H., Gerard, R.D., Rothermel, B.A., Hill, J.A. Circulation (2006)
- Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. Altomonte, J., Cong, L., Harbaran, S., Richter, A., Xu, J., Meseck, M., Dong, H.H. J. Clin. Invest. (2004)
- Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Furuyama, T., Kitayama, K., Yamashita, H., Mori, N. Biochem. J. (2003)
- Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, K.C., Herrera, P.L., Noda, T., Kasuga, M. Nat. Genet. (2006)
- Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nakae, J., Biggs, W.H., Kitamura, T., Cavenee, W.K., Wright, C.V., Arden, K.C., Accili, D. Nat. Genet. (2002)
- Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Puigserver, P., Rhee, J., Donovan, J., Walkey, C.J., Yoon, J.C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., Spiegelman, B.M. Nature (2003)
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W.H., Wright, C.V., White, M.F., Arden, K.C., Accili, D. J. Clin. Invest. (2002)
- Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. Furuyama, T., Kitayama, K., Shimoda, Y., Ogawa, M., Sone, K., Yoshida-Araki, K., Hisatsune, H., Nishikawa, S., Nakayama, K., Nakayama, K., Ikeda, K., Motoyama, N., Mori, N. J. Biol. Chem. (2004)
- Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt. Nakae, J., Kitamura, T., Ogawa, W., Kasuga, M., Accili, D. Biochemistry (2001)
- Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Altomonte, J., Richter, A., Harbaran, S., Suriawinata, J., Nakae, J., Thung, S.N., Meseck, M., Accili, D., Dong, H. Am. J. Physiol. Endocrinol. Metab. (2003)
- Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes. Valverde, A.M., Mur, C., Brownlee, M., Benito, M. Mol. Biol. Cell (2004)
- Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Samuel, V.T., Choi, C.S., Phillips, T.G., Romanelli, A.J., Geisler, J.G., Bhanot, S., McKay, R., Monia, B., Shutter, J.R., Lindberg, R.A., Shulman, G.I., Veniant, M.M. Diabetes (2006)
- Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., Kubota, N., Terauchi, Y., Froguel, P., Nakae, J., Kasuga, M., Accili, D., Tobe, K., Ueki, K., Nagai, R., Kadowaki, T. J. Biol. Chem. (2004)
- Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Kodama, S., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume, S., Sakakida, M., Araki, E. Biochem. Biophys. Res. Commun. (2005)
- Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. Nakae, J., Park, B.C., Accili, D. J. Biol. Chem. (1999)
- Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. Sekine, K., Chen, Y.R., Kojima, N., Ogata, K., Fukamizu, A., Miyajima, A. EMBO J. (2007)
- Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Naïmi, M., Gautier, N., Chaussade, C., Valverde, A.M., Accili, D., Van Obberghen, E. Endocrinology (2007)
- Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway. Göncz, E., Strowski, M.Z., Grötzinger, C., Nowak, K.W., Kaczmarek, P., Sassek, M., Mergler, S., El-Zayat, B.F., Theodoropoulou, M., Stalla, G.K., Wiedenmann, B., Plöckinger, U. Endocrinology (2008)
- Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins. Richards, J.S., Sharma, S.C., Falender, A.E., Lo, Y.H. Mol. Endocrinol. (2002)
- IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Valverde, A.M., Fabregat, I., Burks, D.J., White, M.F., Benito, M. Hepatology (2004)
- Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Hosaka, T., Biggs, W.H., Tieu, D., Boyer, A.D., Varki, N.M., Cavenee, W.K., Arden, K.C. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Aoyama, H., Daitoku, H., Fukamizu, A. Int. J. Mol. Med. (2006)
- A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. Kitamura, T., Kitamura, Y.I., Funahashi, Y., Shawber, C.J., Castrillon, D.H., Kollipara, R., DePinho, R.A., Kitajewski, J., Accili, D. J. Clin. Invest. (2007)
- Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. Kim, S.J., Winter, K., Nian, C., Tsuneoka, M., Koda, Y., McIntosh, C.H. J. Biol. Chem. (2005)
- Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Contreras, J.L., Smyth, C.A., Bilbao, G., Young, C.J., Thompson, J.A., Eckhoff, D.E. Transplantation (2002)
- Regulation of alkaline phosphatase promoter activity by forkhead transcription factor FKHR. Hatta, M., Daitoku, H., Matsuzaki, H., Deyama, Y., Yoshimura, Y., Suzuki, K., Matsumoto, A., Fukamizu, A. Int. J. Mol. Med. (2002)