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Gene Review

B2M  -  beta-2-microglobulin

Homo sapiens

Synonyms: Beta-2-microglobulin, CDABP0092, HDCMA22P
 
 
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Disease relevance of B2M

 

Psychiatry related information on B2M

 

High impact information on B2M

 

Chemical compound and disease context of B2M

 

Biological context of B2M

 

Anatomical context of B2M

 

Associations of B2M with chemical compounds

 

Physical interactions of B2M

  • We now show that the extracellular region of HLA-E forms a stable complex with beta2 microglobulin and can be refolded around synthetic peptide [33].
  • Co-immunoprecipitation studies of cell lysates from human embryonic kidney cells transfected with wild-type or mutant HLA-H cDNA demonstrate that wild-type HLA-H binds beta2-microglobulin and that the C282Y mutation, but not the H63D mutation, completely abrogates this interaction [34].
  • The identification of the beta 2-microglobulin binding antigen encoded by the human CD1D gene [35].
  • Dissociation of human beta-2-microglobulin (beta(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein [36].
  • The latter residue is the only one to differ between human and mouse beta 2-mu in the stretch of amino acids interacting with the alpha 1 and alpha 2 domains of HLA class I heavy chains.(ABSTRACT TRUNCATED AT 400 WORDS)[37]
 

Enzymatic interactions of B2M

 

Co-localisations of B2M

 

Regulatory relationships of B2M

 

Other interactions of B2M

  • HLA-A and HLA-B antigens are integral membrane glycoproteins which consist of a glycosylated heavy chain embedded in the membrane in noncovalent association with beta 2-microglobulin, a water-soluble polypeptide [28].
  • Here, we show that the related chaperone, calreticulin, binds human class I-beta 2m dimers prior to peptide loading [25].
  • These data add further support to the hypothesis proposing a role for alpha 2-M and other antiproteases in the formation and/or persistence of beta 2-m amyloidosis [46].
  • However, sequential immunoprecipitation with monoclonal antibody W6/32 followed by monoclonal antibody G233 continued to detect a residual band of 39 kDa, suggesting that trophoblast surface HLA-G may also occur as free heavy chains not associated with beta 2 m [43].
  • Therefore, using RT-PCR, we have investigated the HLA class I transcriptional expression in a locus-specific manner, along with HLA-associated accessory molecules beta2-microglobulin and transporter-associated antigen processing molecule (TAP1) [47].
 

Analytical, diagnostic and therapeutic context of B2M

References

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  30. Peritoneal transport characteristics with glucose polymer based dialysate. Ho-dac-Pannekeet, M.M., Schouten, N., Langendijk, M.J., Hiralall, J.K., de Waart, D.R., Struijk, D.G., Krediet, R.T. Kidney Int. (1996) [Pubmed]
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