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Gene Review

Miox  -  myo-inositol oxygenase

Mus musculus

Synonyms: 0610009I10Rik, AI314022, Aldehyde reductase-like 6, Aldrl6, C85427, ...
 
 
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Disease relevance of Miox

 

High impact information on Miox

  • The RSOR expression also increased in cells treated with various organic osmolytes, e.g., sorbitol, myoinositol, and glycerolphosphoryl-choline and H(2)O(2) [5].
  • Data indicate that RSOR activity is modulated by diverse mechanisms, and it is endowed with dual properties to channel glucose intermediaries, characteristic of hepatic aldehyde reductases, and to maintain osmoregulation, a function of renal medullary genes, e.g., aldose reductase, in diabetes [5].
  • Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development [4].
  • This may partly be related to the differential degree of apoptosis, a process reflective of oxidant stress that is seen in diabetic milieu, which as previously has been shown to adversely effect the modulators of fetal development and thereby the morphogenesis of the kidney and RSOR expression [4].
  • Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development [2].
 

Anatomical context of Miox

 

Associations of Miox with chemical compounds

 

Analytical, diagnostic and therapeutic context of Miox

References

  1. Identification of a renal-specific oxido-reductase in newborn diabetic mice. Yang, Q., Dixit, B., Wada, J., Tian, Y., Wallner, E.I., Srivastva, S.K., Kanwar, Y.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development. Kanwar, Y.S., Yang, Q., Tian, Y., Lin, S., Wada, J., Chugh, S., Srivastava, S.K. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  3. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. Arner, R.J., Prabhu, K.S., Reddy, C.C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development. Kanwar, Y.S., Akagi, S., Nayak, B., Sun, L., Wada, J., Xie, P., Thakur, A., Chugh, S.S., Danesh, F.R. Kidney Int. (2005) [Pubmed]
  5. Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience. Nayak, B., Xie, P., Akagi, S., Yang, Q., Sun, L., Wada, J., Thakur, A., Danesh, F.R., Chugh, S.S., Kanwar, Y.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Relevance of extracellular matrix and its receptors in mammalian nephrogenesis revealed by metanephric organ culture system. Wada, J., Kanwar, Y.S., Makino, H. Nephrol. Dial. Transplant. (2002) [Pubmed]
  7. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. Arner, R.J., Prabhu, K.S., Thompson, J.T., Hildenbrandt, G.R., Liken, A.D., Reddy, C.C. Biochem. J. (2001) [Pubmed]
  8. Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Brown, P.M., Caradoc-Davies, T.T., Dickson, J.M., Cooper, G.J., Loomes, K.M., Baker, E.N. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
 
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