Gene Review:
MEPE - matrix extracellular phosphoglycoprotein
Homo sapiens
Synonyms:
Matrix extracellular phosphoglycoprotein, OF45, Osteoblast/osteocyte factor 45
Rowe,
de Zoysa,
Dong,
Wang,
White,
Econs,
Oudet,
Koscielniak-Nielsen,
Rotbøll Nielsen,
Sørensen,
Stenør,
Liu,
Rowe,
Vierthaler,
Zhou,
Quarles,
Laroche,
Boyer,
Rowe,
Garrett,
Schwarz,
Carnes,
Lafer,
Mundy,
Gutierrez,
Siggelkow,
Schmidt,
Hennies,
Hüfner,
Fisher,
Fedarko,
Quarles,
MacDougall,
Simmons,
Gu,
Dong,
- MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Rowe, P.S., de Zoysa, P.A., Dong, R., Wang, H.R., White, K.E., Econs, M.J., Oudet, C.L. Genomics (2000)
- Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. Bresler, D., Bruder, J., Mohnike, K., Fraser, W.D., Rowe, P.S. J. Endocrinol. (2004)
- The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. Lee, K.S., Kim, J., Yoon, Y.W., Lee, M.G., Hong, S.K., Han, H.C. Neurosci. Lett. (2007)
- Low dose axillary block by targeted injections of the terminal nerves. Koscielniak-Nielsen, Z.J., Rotbøll Nielsen, P., Sørensen, T., Stenør, M. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1999)
- Coexpression of CCR5 and IL-2 in human genital but not blood T cells: implications for the ontogeny of the CCR5+ Th1 phenotype. Hladik, F., Lentz, G., Delpit, E., McElroy, A., McElrath, M.J. J. Immunol. (1999)
- A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo. Hayashibara, T., Hiraga, T., Yi, B., Nomizu, M., Kumagai, Y., Nishimura, R., Yoneda, T. J. Bone Miner. Res. (2004)
- FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. Quarles, L.D. Am. J. Physiol. Endocrinol. Metab. (2003)
- Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Argiro, L., Desbarats, M., Glorieux, F.H., Ecarot, B. Genomics (2001)
- Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. Liu, S., Rowe, P.S., Vierthaler, L., Zhou, J., Quarles, L.D. J. Endocrinol. (2007)
- Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Ogbureke, K.U., Fisher, L.W. Kidney Int. (2005)
- Expression of SIBLINGs and their partner MMPs in salivary glands. Ogbureke, K.U., Fisher, L.W. J. Dent. Res. (2004)
- MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. MacDougall, M., Simmons, D., Gu, T.T., Dong, J. Connect. Tissue Res. (2002)
- Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Fisher, L.W., Fedarko, N.S. Connect. Tissue Res. (2003)
- Structural analysis of a metallosupramolecular polyelectrolyte-amphiphile complex at the air/water interface. Lehmann, P., Kurth, D.G., Brezesinski, G., Symietz, C. Chemistry (Weinheim an der Bergstrasse, Germany) (2001)
- Evidence of downregulation of matrix extracellular phosphoglycoprotein during terminal differentiation in human osteoblasts. Siggelkow, H., Schmidt, E., Hennies, B., Hüfner, M. Bone (2004)
- Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). Rowe, P.S., Garrett, I.R., Schwarz, P.M., Carnes, D.L., Lafer, E.M., Mundy, G.R., Gutierrez, G.E. Bone (2005)
- Phosphate diabetes, tubular phosphate reabsorption and phosphatonins. Laroche, M., Boyer, J.F. Joint, bone, spine : revue du rhumatisme. (2005)
- A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors. Nagel, D.E., Khosla, S., Sanyal, A., Rosen, D.M., Kumagai, Y., Riggs, B.L. J. Cell. Biochem. (2004)
- MEPE is downregulated as dental pulp stem cells differentiate. Liu, H., Li, W., Shi, S., Habelitz, S., Gao, C., Denbesten, P. Arch. Oral Biol. (2005)
- Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. Jain, A., Fedarko, N.S., Collins, M.T., Gelman, R., Ankrom, M.A., Tayback, M., Fisher, L.W. J. Clin. Endocrinol. Metab. (2004)
- Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. Nampei, A., Hashimoto, J., Hayashida, K., Tsuboi, H., Shi, K., Tsuji, I., Miyashita, H., Yamada, T., Matsukawa, N., Matsumoto, M., Morimoto, S., Ogihara, T., Ochi, T., Yoshikawa, H. J. Bone Miner. Metab. (2004)