Gene Review:
PSMB9 - proteasome (prosome, macropain) subunit,...
Homo sapiens
Synonyms:
LMP2, Low molecular mass protein 2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, PSMB6i, ...
Frisan,
Levitsky,
Polack,
Masucci,
Maksymowych,
Ikawa,
Yamaguchi,
Ikeda,
McDonald,
Laouar,
Lahesmaa,
Tamura,
Khuong,
Yu,
Kane,
Krause,
Kuckelkorn,
Dörner,
Burmester,
Feist,
Kloetzel,
Mishto,
Bellavista,
Santoro,
Stolzing,
Ligorio,
Nacmias,
Spazzafumo,
Chiappelli,
Licastro,
Sorbi,
Pession,
Ohm,
Grune,
Franceschi,
- Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders. Krause, S., Kuckelkorn, U., Dörner, T., Burmester, G.R., Feist, E., Kloetzel, P.M. Ann. Rheum. Dis. (2006)
- Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501. Heward, J.M., Allahabadia, A., Sheppard, M.C., Barnett, A.H., Franklyn, J.A., Gough, S.C. Clin. Endocrinol. (Oxf) (1999)
- Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome. Khan, M.A., Oubrahim, H., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line. Dovhey, S.E., Ghosh, N.S., Wright, K.L. Cancer Res. (2000)
- Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. Kageshita, T., Hirai, S., Ono, T., Hicklin, D.J., Ferrone, S. Am. J. Pathol. (1999)
- Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., Pession, A., Ohm, T., Grune, T., Franceschi, C. Neurobiol. Aging (2006)
- Antigen processing and presentation by the class I major histocompatibility complex. York, I.A., Rock, K.L. Annu. Rev. Immunol. (1996)
- Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Gaczynska, M., Rock, K.L., Goldberg, A.L. Nature (1993)
- Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Martinez, C.K., Monaco, J.J. Nature (1991)
- Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Miller, C.L., Burkhardt, A.L., Lee, J.H., Stealey, B., Longnecker, R., Bolen, J.B., Kieff, E. Immunity (1995)
- Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. Poole, L.J., Zong, J.C., Ciufo, D.M., Alcendor, D.J., Cannon, J.S., Ambinder, R., Orenstein, J.M., Reitz, M.S., Hayward, G.S. J. Virol. (1999)
- Proteasome inhibitors reconstitute the presentation of cytotoxic T-cell epitopes in Epstein-Barr virus-associated tumors. Gavioli, R., Vertuani, S., Masucci, M.G. Int. J. Cancer (2002)
- Polymorphisms of transporter associated with antigen processing type 1 (TAP1), proteasome subunit beta type 9 (PSMB9) and their common promoter in African children with different manifestations of malaria. Niesporek, S., Meyer, C.G., Kremsner, P.G., May, J. International journal of immunogenetics. (2005)
- Delineation of the subunit composition of human proteasomes using antisera against the major histocompatibility complex-encoded LMP2 and LMP7 subunits. Patel, S.D., Monaco, J.J., McDevitt, H.O. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex. Schmidt, M., Zantopf, D., Kraft, R., Kostka, S., Preissner, R., Kloetzel, P.M. J. Mol. Biol. (1999)
- Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Arnold, D., Driscoll, J., Androlewicz, M., Hughes, E., Cresswell, P., Spies, T. Nature (1992)
- Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA. Singal, D.P., Ye, M., Quadri, S.A. J. Biol. Chem. (1995)
- IFN-gamma-mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma. Seliger, B., Hammers, S., Höhne, A., Zeidler, R., Knuth, A., Gerharz, C.D., Huber, C. Clin. Cancer Res. (1997)
- Variations in proteasome subunit composition and enzymatic activity in B-lymphoma lines and normal B cells. Frisan, T., Levitsky, V., Masucci, M.G. Int. J. Cancer (2000)
- Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. Wang, H.X., Wang, H.M., Lin, H.Y., Yang, Q., Zhang, H., Tsang, B.K., Zhu, C. J. Cell. Physiol. (2006)
- Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. Hisamatsu, H., Shimbara, N., Saito, Y., Kristensen, P., Hendil, K.B., Fujiwara, T., Takahashi, E., Tanahashi, N., Tamura, T., Ichihara, A., Tanaka, K. J. Exp. Med. (1996)
- Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein. Gileadi, U., Moins-Teisserenc, H.T., Correa, I., Booth, B.L., Dunbar, P.R., Sewell, A.K., Trowsdale, J., Phillips, R.E., Cerundolo, V. J. Immunol. (1999)
- Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. Zhang, Y., Jamaluddin, M., Wang, S., Tian, B., Garofalo, R.P., Casola, A., Brasier, A.R. J. Virol. (2003)
- Association of immunoproteasomes with the endoplasmic reticulum. Brooks, P., Murray, R.Z., Mason, G.G., Hendil, K.B., Rivett, A.J. Biochem. J. (2000)
- Expression of proteasome subunits low molecular mass polypeptide (LMP) 2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Wang, H.X., Wang, H.M., Li, Q.L., Lin, H.Y., Qian, D., Zhu, C. Biol. Reprod. (2004)
- The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome. Groettrup, M., Standera, S., Stohwasser, R., Kloetzel, P.M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes. Murray, B.W., Sültmann, H., Klein, J. J. Immunol. (1999)
- Impact of the MHC-encoded HLA-DMA, DMB, and LMP2 gene polymorphisms on kidney graft outcome. Chevrier, D., Giral, M., Muller, J.Y., Bignon, J.D., Soulillou, J.P. Hum. Immunol. (1998)
- Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. Wright, K.L., White, L.C., Kelly, A., Beck, S., Trowsdale, J., Ting, J.P. J. Exp. Med. (1995)
- Phenotype-dependent differences in proteasome subunit composition and cleavage specificity in B cell lines. Frisan, T., Levitsky, V., Polack, A., Masucci, M.G. J. Immunol. (1998)
- Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27. Maksymowych, W.P., Ikawa, T., Yamaguchi, A., Ikeda, M., McDonald, D., Laouar, L., Lahesmaa, R., Tamura, N., Khuong, A., Yu, D.T., Kane, K.P. Infect. Immun. (1998)
- cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. Akiyama, K., Yokota, K., Kagawa, S., Shimbara, N., Tamura, T., Akioka, H., Nothwang, H.G., Noda, C., Tanaka, K., Ichihara, A. Science (1994)
- Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis. Burney, R.O., Pile, K.D., Gibson, K., Calin, A., Kennedy, L.G., Sinnott, P.J., Powis, S.H., Wordsworth, B.P. Ann. Rheum. Dis. (1994)