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Gene Review

TULP4  -  tubby like protein 4

Homo sapiens

Synonyms: KIAA1397, TUBL4, TUSP, Tubby superfamily protein, Tubby-like protein 4, ...
 
 
 
 
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High impact information on TULP4

  • Radiation hybrid mapping localized the mouse gene to chromosome 17q13 and the human TUSP gene to chromosome 6q25-q26 near the type 1 diabetes gene IDDM5 [1].
  • However, association analysis in diabetic families with a polymorphic microsatellite marker did not show any evidence for association between TUSP and type 1 diabetes [1].
  • Transfection assay with green fluorescent protein-tagged TUSP expression constructs showed that the complete TUSP protein and the N-terminal portion of TUSP are localized in the cytoplasm but the C-terminal portion with the two NLSs produced distinct dots or spots localized in the cytoplasm [1].
 

Analytical, diagnostic and therapeutic context of TULP4

References

  1. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Li, Q.Z., Wang, C.Y., Shi, J.D., Ruan, Q.G., Eckenrode, S., Davoodi-Semiromi, A., Kukar, T., Gu, Y., Lian, W., Wu, D., She, J.X. Gene (2001) [Pubmed]
 
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