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Gene Review

PSMC2  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, MSS1, Nbla10058, Proteasome 26S subunit ATPase 2, ...
 
 
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Disease relevance of PSMC2

 

High impact information on PSMC2

  • In addition, we provide genetic evidence for a physical interaction between the S4 and the related S7 subunit in the 26S multiprotein protease [4].
  • Tests for association in Duke and AGRE families were also performed on four additional SNPs in the genes PSMC2 and ORC5L, which flank RELN [5].
  • Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase) [6].
  • We have used fluorescence in situ hybridization (FISH) to localize S7 to chromosome 2p25 [7].
  • The S7 gene contains seven exons and six introns spanning about 6 kb [7].
 

Biological context of PSMC2

 

Associations of PSMC2 with chemical compounds

  • In striking contrast, truncation of 85 NH2-terminal amino acids from S4 abrogated binding, clearly implicating the NH2 terminus of S4 in its specific interaction with S7 [11].
 

Physical interactions of PSMC2

  • Progressive COOH-terminal deletions that removed as much as 300 amino acids from S4 had no effect on the binding of S4 to S7 [11].
 

Analytical, diagnostic and therapeutic context of PSMC2

  • By means of chemical cross-linking, immunoprecipitation, and blotting, we have determined that the ATPases are organized in the order S6-S6'-S10b-S8-S4-S7 [12].
  • The Mixed Stain Study 1 (MSS1, Apr.-Nov. 1997) and Mixed Stain Study 2 (MSS2, Jan.-May 1999) evaluated multiplexed short-tandem repeat (STR) DNA typing systems with samples containing DNA from more than one source [13].

References

  1. Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4. Swaffield, J.C., Bromberg, J.F., Johnston, S.A. Nature (1992) [Pubmed]
  2. A homologue of the human MSS1 gene, a positive modulator of HIV-1 gene expression, is massively expressed in Xenopus oocytes. Nacken, W., Kingsman, A.J., Kingsman, S.M., Sablitzky, F., Sorg, C. Biochim. Biophys. Acta (1995) [Pubmed]
  3. Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats. Combaret, L., Rallière, C., Taillandier, D., Tanaka, K., Attaix, D. Mol. Biol. Rep. (1999) [Pubmed]
  4. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon, C., McGurk, G., Dillon, P., Rosen, C., Hastie, N.D. Nature (1993) [Pubmed]
  5. Analysis of the RELN gene as a genetic risk factor for autism. Skaar, D.A., Shao, Y., Haines, J.L., Stenger, J.E., Jaworski, J., Martin, E.R., DeLong, G.R., Moore, J.H., McCauley, J.L., Sutcliffe, J.S., Ashley-Koch, A.E., Cuccaro, M.L., Folstein, S.E., Gilbert, J.R., Pericak-Vance, M.A. Mol. Psychiatry (2005) [Pubmed]
  6. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Turner, R.T., Hong, L., Koelsch, G., Ghosh, A.K., Tang, J. Biochemistry (2005) [Pubmed]
  7. The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. Annilo, T., Laan, M., Stahl, J., Metspalu, A. Gene (1995) [Pubmed]
  8. Gene expression profile changes in NB4 cells induced by realgar. Wang, H., Liu, S., Lu, X., Zhao, X., Chen, S., Li, X. Chin. Med. J. (2003) [Pubmed]
  9. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. Choi, H.S., Seol, W., Moore, D.D. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  10. Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease. Dubiel, W., Ferrell, K., Rechsteiner, M. FEBS Lett. (1993) [Pubmed]
  11. Specific interactions between ATPase subunits of the 26 S protease. Richmond, C., Gorbea, C., Rechsteiner, M. J. Biol. Chem. (1997) [Pubmed]
  12. Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking. Hartmann-Petersen, R., Tanaka, K., Hendil, K.B. Arch. Biochem. Biophys. (2001) [Pubmed]
  13. NIST mixed stain studies #1 and #2: interlaboratory comparison of DNA quantification practice and short tandem repeat multiplex performance with multiple-source samples. Duewer, D.L., Kline, M.C., Redman, J.W., Newall, P.J., Reeder, D.J. J. Forensic Sci. (2001) [Pubmed]
 
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