Gene Review:
PTGDS - prostaglandin D2 synthase 21kDa (brain)
Homo sapiens
Synonyms:
Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, L-PGDS, LPGDS, ...
Morosetti,
Servidei,
Mirabella,
Rutella,
Mangiola,
Maira,
Mastrangelo,
Koeffler,
White,
Takeda,
DeGroot,
Stefansson,
Arnason,
Cipollone,
Fazia,
Iezzi,
Ciabattoni,
Pini,
Cuccurullo,
Ucchino,
Spigonardo,
De Luca,
Prontera,
Chiarelli,
Cuccurullo,
Mezzetti,
Maesaka,
Palaia,
Fishbane,
Ragolia,
Yagami,
Ueda,
Asakura,
Hata,
Kuroda,
Sakaeda,
Takasu,
Tanaka,
Gemba,
Hori,
Jordan,
Tumani,
Cohrs,
Eggert,
Rodenbeck,
Brunner,
Rüther,
Hajak,
Mindrescu,
Le,
Wisniewski,
Vilcek,
Andrei Drabovich,
Hiraoka,
Seiki,
Oda,
Eguchi,
Urade,
Tominaga,
Baba,
Tokugawa,
Kunishige,
Kubota,
Shimoya,
Nobunaga,
Kimura,
Saji,
Murata,
Eguchi,
Oda,
Urade,
Hayaishi,
- Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma. Drabovich, A.P., Dimitromanolakis, A., Saraon, P., Soosaipillai, A., Batruch, I., Mullen, B., Jarvi, K., Diamandis, E.P. Sci. Transl. Med. (2013)
- Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay. Drabovich, A.P., Jarvi, K., Diamandis, E.P. Mol. Cell. Proteomics. (2011)
- Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Eguchi, Y., Eguchi, N., Oda, H., Seiki, K., Kijima, Y., Matsu-ura, Y., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Urinary prostaglandin D synthase (beta-trace) excretion increases in the early stage of diabetes mellitus. Hirawa, N., Uehara, Y., Ikeda, T., Gomi, T., Hamano, K., Totsuka, Y., Yamakado, M., Takagi, M., Eguchi, N., Oda, H., Seiki, K., Nakajima, H., Urade, Y. Nephron (2001)
- Lipocalin-type prostaglandin d synthase in essential hypertension. Hirawa, N., Uehara, Y., Yamakado, M., Toya, Y., Gomi, T., Ikeda, T., Eguchi, Y., Takagi, M., Oda, H., Seiki, K., Urade, Y., Umemura, S. Hypertension (2002)
- Prostaglandin D synthase (beta-trace) in healthy human sleep. Jordan, W., Tumani, H., Cohrs, S., Eggert, S., Rodenbeck, A., Brunner, E., Rüther, E., Hajak, G. Sleep. (2004)
- Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Chen, C., Bazan, N.G. Prostaglandins Other Lipid Mediat. (2005)
- Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. Kim, J., Yang, P., Suraokar, M., Sabichi, A.L., Llansa, N.D., Mendoza, G., Subbarayan, V., Logothetis, C.J., Newman, R.A., Lippman, S.M., Menter, D.G. Cancer Res. (2005)
- Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia. Maesaka, J.K., Palaia, T., Fishbane, S., Ragolia, L. Semin. Nephrol. (2002)
- MMPI discriminators of deficit vs. non-deficit recent-onset schizophrenia patients. Subotnik, K.L., Nuechterlein, K.H., Ventura, J. Psychiatry research. (2000)
- Prostaglandin D2 as a mediator of allergic asthma. Matsuoka, T., Hirata, M., Tanaka, H., Takahashi, Y., Murata, T., Kabashima, K., Sugimoto, Y., Kobayashi, T., Ushikubi, F., Aze, Y., Eguchi, N., Urade, Y., Yoshida, N., Kimura, K., Mizoguchi, A., Honda, Y., Nagai, H., Narumiya, S. Science (2000)
- Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Wang, Y.H., Ito, T., Wang, Y.H., Homey, B., Watanabe, N., Martin, R., Barnes, C.J., McIntyre, B.W., Gilliet, M., Kumar, R., Yao, Z., Liu, Y.J. Immunity (2006)
- Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. Mandal, A.K., Zhang, Z., Ray, R., Choi, M.S., Chowdhury, B., Pattabiraman, N., Mukherjee, A.B. J. Exp. Med. (2004)
- Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. Kilunga Kubata, B., Eguchi, N., Urade, Y., Yamashita, K., Mitamura, T., Tai, K., Hayaishi, O., Horii, T. J. Exp. Med. (1998)
- Antigen-induced generation of lyso-phospholipids in human airways. Chilton, F.H., Averill, F.J., Hubbard, W.C., Fonteh, A.N., Triggiani, M., Liu, M.C. J. Exp. Med. (1996)
- The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Morosetti, R., Servidei, T., Mirabella, M., Rutella, S., Mangiola, A., Maira, G., Mastrangelo, R., Koeffler, H.P. Int. J. Oncol. (2004)
- Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Kuno, S., Ueno, R., Hayaishi, O., Nakashima, H., Harada, S., Yamamoto, N. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation. Smith, J.B., Araki, H., Lefer, A.M. Circulation (1980)
- Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells. Miyagi, M., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., Sasaguri, T. Arterioscler. Thromb. Vasc. Biol. (2005)
- Micropurification of two human cerebrospinal fluid proteins by high performance electrophoresis chromatography. Leone, M.G., Saso, L., Del Vecchio, A., Mo, M.Y., Silvestrini, B., Cheng, C.Y. J. Neurochem. (1993)
- Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Tokugawa, Y., Kunishige, I., Kubota, Y., Shimoya, K., Nobunaga, T., Kimura, T., Saji, F., Murata, Y., Eguchi, N., Oda, H., Urade, Y., Hayaishi, O. Biol. Reprod. (1998)
- Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. Cipollone, F., Fazia, M., Iezzi, A., Ciabattoni, G., Pini, B., Cuccurullo, C., Ucchino, S., Spigonardo, F., De Luca, M., Prontera, C., Chiarelli, F., Cuccurullo, F., Mezzetti, A. Arterioscler. Thromb. Vasc. Biol. (2004)
- Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Chan, E.S., Zhang, H., Fernandez, P., Edelman, S.D., Pillinger, M.H., Ragolia, L., Palaia, T., Carsons, S., Reiss, A.B. Arthritis Res. Ther. (2007)
- Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. White, D.M., Takeda, T., DeGroot, L.J., Stefansson, K., Arnason, B.G. J. Biol. Chem. (1997)
- Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. Yagami, T., Ueda, K., Asakura, K., Hata, S., Kuroda, T., Sakaeda, T., Takasu, N., Tanaka, K., Gemba, T., Hori, Y. Mol. Pharmacol. (2002)
- Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets. Tanaka, K., Ogawa, K., Sugamura, K., Nakamura, M., Takano, S., Nagata, K. J. Immunol. (2000)
- Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents. Longo, W.E., Panesar, N., Mazuski, J., Kaminski, D.L. Prostaglandins Other Lipid Mediat. (1998)
- Up-regulation of cyclooxygenase-2 expression by TSG-6 protein in macrophage cell line. Mindrescu, C., Le, J., Wisniewski, H.G., Vilcek, J. Biochem. Biophys. Res. Commun. (2005)
- IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. Obata, T., Nagakura, T., Kanbe, M., Masaki, T., Maekawa, K., Yamashita, K. Biochem. Biophys. Res. Commun. (1996)
- Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing. Hiraoka, A., Seiki, K., Oda, H., Eguchi, N., Urade, Y., Tominaga, I., Baba, K. Electrophoresis (2001)
- Purification and N-terminal sequence of beta-trace, a protein abundant in human cerebrospinal fluid. Zahn, M., Mäder, M., Schmidt, B., Bollensen, E., Felgenhauer, K. Neurosci. Lett. (1993)
- Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology. Harrington, M.G., Fonteh, A.N., Biringer, R.G., R Hühmer, A.F., Cowan, R.P. Dis. Markers (2006)