Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PTGER1 - prostaglandin E receptor 1 (subtype EP1),...

Homo sapiens

Synonyms: EP1, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostaglandin E2 receptor EP1 subtype, Prostanoid EP1 receptor

Ohia, S.E. et al., Grigsby, P.L. et al., Smith, G.C. et al., Duncan, A.M. et al.

Grigsby, Sooranna, Adu-Amankwa, Pitzer, Brockman, Johnson, Myatt,

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High impact information on PTGER1

A change in intracellular localization was observed at term labor, where PTGER1 and PTGER4 were predominately associated with the nucleus [1].
The PTGER1, TBXA2R, and PTGIR genes mapped to chromosome 19 at positions 19p13.1, 19p13.3, and 19q13.3, respectively [2].
PGE2-mediated inhibition was not antagonized by the selective prostanoid EP1-receptor antagonists AH 6809 (10 microM) or SC-19220 (30 microM), nor did these agents alone affect basal or field-stimulated 3H-NE release [3].
Expression of the gene encoding the prostanoid EP1 receptor increased with advancing gestational age prior to labor (r2 = 0.8, P = 0.007) [4].

References

Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Grigsby, P.L., Sooranna, S.R., Adu-Amankwa, B., Pitzer, B., Brockman, D.E., Johnson, M.R., Myatt, L. Biol. Reprod. (2006) [Pubmed]
Chromosomal localization of the human prostanoid receptor gene family. Duncan, A.M., Anderson, L.L., Funk, C.D., Abramovitz, M., Adam, M. Genomics (1995) [Pubmed]
Prejunctional prostaglandin receptors in the human iris-ciliary body. Ohia, S.E., Jumblatt, J.E. Curr. Eye Res. (1991) [Pubmed]
Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix. Smith, G.C., Wu, W.X., Nathanielsz, P.W. Prostaglandins Other Lipid Mediat. (2001) [Pubmed]

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