Disease relevance of Smarce1

• Lastly, we demonstrate that both BAF57 and BRM are required for the proliferation of AR-dependent prostatic adenocarcinoma cells [1].

High impact information on Smarce1

• Our data reveal that BAF57 can directly bind to the AR and is recruited to endogenous AR targets upon ligand activation [1].
• This action of BAF57 proved to be dependent on SWI/SNF ATPase function [1].
• The unique arrangement of an HMG with a KLCC domain shared with Smarce1/BAF-57 suggests a similar, albeit still unknown, function in chromatin assembly as part of a mammalian SWI/SNF-like complex [2].
• Here, we show that BAF57 and BRG1, two essential subunits of murine SWI/SNF complex, differentially associate with the DNase I hypersensitive region HS1/2 of 3'E and the IgG2b germline promoter in response to LPS activation or CD40 engagement [3].

Chemical compound and disease context of Smarce1

• We show that BAF57 is expressed in the luminal epithelia of the prostate and is required for AR-dependent transactivation in prostatic adenocarcinoma cells [1].

Associations of Smarce1 with chemical compounds

• BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF [1].

References