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Gene Review: 

Psors1c2  -  psoriasis susceptibility 1 candidate 2...

Mus musculus

Synonyms: AI448740, Pcg, Protein SPR1, Psoriasis susceptibility 1 candidate gene 2 protein homolog, SPR1, ...
 
 
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Disease relevance of Psors1c2

 

High impact information on Psors1c2

  • To explore their properties, we expressed in bacteria a recombinant human SPR1 protein and isolated native SPR1 proteins from cultured mouse keratinocytes [3].
  • We studied the expression and regulation of SPR1 in a series of human bronchial epithelial cell lines representing a model of multistep bronchial carcinogenesis [2].
  • Assessment of keratinocyte differentiation-specific protein expression in neoplastic cells revealed that expression of the suprabasal marker SPR-1 and the granular markers loricrin and filaggrin were induced by stsp [4].
  • Radiation potentiated granular cell-differentiation marker expressions (filaggrin, loricrin, and SPR-1) in both normal and v-rasHa transformed cells [5].

References

  1. Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. Holm, S.J., Carlén, L.M., Mallbris, L., Ståhle-Bäckdahl, M., O'Brien, K.P. Exp. Dermatol. (2003)
  2. Expression and regulation of a molecular marker, SPR1, in multistep bronchial carcinogenesis. Lau, D., Xue, L., Hu, R., Liaw, T., Wu, R., Reddy, S. Am. J. Respir. Cell Mol. Biol. (2000)
  3. Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin. Candi, E., Tarcsa, E., Idler, W.W., Kartasova, T., Marekov, L.N., Steinert, P.M. J. Biol. Chem. (1999)
  4. Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C. Stanwell, C., Dlugosz, A.A., Yuspa, S.H. Carcinogenesis (1996)
  5. Increased induction of Ca2+-mediated differentiation by gamma ray is mediated by endogenous activation of the protein kinase C signaling pathways in mouse epidermal cells. Song, H.J., Cho, C.K., Yoo, S.Y., Park, K.S., Lee, Y.S. Int. J. Radiat. Oncol. Biol. Phys. (1998)
 

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