Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MIF - macrophage migration inhibitory factor...

Macaca mulatta

Synonyms: L-dopachrome isomerase, L-dopachrome tautomerase, Macrophage migration inhibitory factor, Phenylpyruvate tautomerase

Crowley, T.J. et al.

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Psychiatry related information on MIF

Earlier dose-response studies in unanesthetized monkeys had shown that this dose of MIF stimulated motor activity; this dose of TRH had shown no stimulant effect, but a higher dose depressed activity [1].

High impact information on MIF

Thus, an MIF dose that stimulates unanesthetized monkeys does not reverse pentobarbital narcosis; a TRH dose that by itself is neither stimulant nor depressant does partially reverse pentobarbital narcosis [1].
Thyrotropin-releasing hormone (TRH), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting factor (MIF), 0.1 mg/kg i.m., did not [1].

References

Comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys. Crowley, T.J., Hydinger, M. Psychopharmacology (Berl.) (1977) [Pubmed]

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