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Gene Review

ARHGAP31  -  Rho GTPase activating protein 31

Homo sapiens

Synonyms: AOS1, CDGAP, Cdc42 GTPase-activating protein, KIAA1204, Rho GTPase-activating protein 31
 
 
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High impact information on CDGAP

  • Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes [1].
  • We report that the mRNA and protein levels of CdGAP are increased upon serum stimulation and that GSK-3 activity is necessary for the up-regulation of the protein levels of CdGAP but not for the increase in mRNA [2].

References

  1. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Wang, L., Yang, L., Debidda, M., Witte, D., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Glycogen Synthase Kinase-3 Phosphorylates CdGAP at a Consensus ERK 1 Regulatory Site. Danek, E.I., Tcherkezian, J., Triki, I., Meriane, M., Lamarche-Vane, N. J. Biol. Chem. (2007) [Pubmed]
 
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