Gene Review:
RPTOR - regulatory associated protein of MTOR,...
Homo sapiens
Synonyms:
KIAA1303, KOG1, Mip1, RAPTOR, Raptor, ...
- Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Kudchodkar, S.B., Yu, Y., Maguire, T.G., Alwine, J.C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Iwamaru, A., Kondo, Y., Iwado, E., Aoki, H., Fujiwara, K., Yokoyama, T., Mills, G.B., Kondo, S. Oncogene (2007)
- Hypersensitivity pneumonitis in a raptor handler and a wild bird fancier. Choy, A.C., Patterson, R., Ray, A.H., Roberts, M. Ann. Allergy Asthma Immunol. (1995)
- Lead poisoning of raptors in France and elsewhere. Pain, D.J., Amiard-Triquet, C. Ecotoxicol. Environ. Saf. (1993)
- Investigation into the seroprevalence of falcon herpesvirus antibodies in raptors in the UK using virus neutralization tests and different herpesvirus isolates. Zsivanovits, P., Forbes, N.A., Zvonar, L.T., Williams, M.R., Lierz, M., Prusas, C., Hafez, M.M. Avian Pathol. (2004)
- mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Holz, M.K., Ballif, B.A., Gygi, S.P., Blenis, J. Cell (2005)
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Kim, D.H., Sarbassov, D.D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. Cell (2002)
- PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase. Sancak, Y., Thoreen, C.C., Peterson, T.R., Lindquist, R.A., Kang, S.A., Spooner, E., Carr, S.A., Sabatini, D.M. Mol. Cell (2007)
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Sarbassov, d.o.s. .D., Ali, S.M., Sengupta, S., Sheen, J.H., Hsu, P.P., Bagley, A.F., Markhard, A.L., Sabatini, D.M. Mol. Cell (2006)
- Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Tzatsos, A., Kandror, K.V. Mol. Cell. Biol. (2006)
- The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Hidayat, S., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., Yonezawa, K. J. Biol. Chem. (2003)
- Rheb binds and regulates the mTOR kinase. Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., Avruch, J. Curr. Biol. (2005)
- Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Liu, L., Li, F., Cardelli, J.A., Martin, K.A., Blenis, J., Huang, S. Oncogene (2006)
- Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size. Eguchi, S., Tokunaga, C., Hidayat, S., Oshiro, N., Yoshino, K., Kikkawa, U., Yonezawa, K. Genes Cells (2006)
- Health effects of endocrine-disrupting chemicals on wildlife, with special reference to the European situation. Vos, J.G., Dybing, E., Greim, H.A., Ladefoged, O., Lambré, C., Tarazona, J.V., Brandt, I., Vethaak, A.D. Crit. Rev. Toxicol. (2000)
- Species variation in osmotic, cryoprotectant, and cooling rate tolerance in poultry, eagle, and peregrine falcon spermatozoa. Blanco, J.M., Gee, G., Wildt, D.E., Donoghue, A.M. Biol. Reprod. (2000)
- Improved fluoroimmunoassays using the dye Alexa Fluor 647 with the RAPTOR, a fiber optic biosensor. Anderson, G.P., Nerurkar, N.L. J. Immunol. Methods (2002)
- Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. McMahon, L.P., Yue, W., Santen, R.J., Lawrence, J.C. Mol. Endocrinol. (2005)
- PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Ha, S.H., Kim, D.H., Kim, I.S., Kim, J.H., Lee, M.N., Lee, H.J., Kim, J.H., Jang, S.K., Suh, P.G., Ryu, S.H. Cell. Signal. (2006)
- Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. Long, X., Ortiz-Vega, S., Lin, Y., Avruch, J. J. Biol. Chem. (2005)
- Western sandpipers have altered migration tactics as peregrine falcon populations have recovered. Ydenberg, R.C., Butler, R.W., Lank, D.B., Smith, B.D., Ireland, J. Proc. Biol. Sci. (2004)
- In silico prediction of harmful effects triggered by drugs and chemicals. Vedani, A., Dobler, M., Lill, M.A. Toxicol. Appl. Pharmacol. (2005)
- TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Schalm, S.S., Fingar, D.C., Sabatini, D.M., Blenis, J. Curr. Biol. (2003)
- Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage. Stuart, P., Nair, R.P., Abecasis, G.R., Nistor, I., Hiremagalore, R., Chia, N.V., Qin, Z.S., Thompson, R.A., Jenisch, S., Weichenthal, M., Janiga, J., Lim, H.W., Christophers, E., Voorhees, J.J., Elder, J.T. J. Med. Genet. (2006)
- Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Oshiro, N., Yoshino, K., Hidayat, S., Tokunaga, C., Hara, K., Eguchi, S., Avruch, J., Yonezawa, K. Genes Cells (2004)
- Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. Kimball, S.R., Jefferson, L.S. J. Nutr. (2006)
- Genetic analysis of PSORS2 markers in a UK dataset supports the association between RAPTOR SNPs and familial psoriasis. Capon, F., Helms, C., Veal, C.D., Tillman, D., Burden, A.D., Barker, J.N., Bowcock, A.M., Trembath, R.C. J. Med. Genet. (2004)
- Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. Wang, L., Rhodes, C.J., Lawrence, J.C. J. Biol. Chem. (2006)
- Raptor protein contains a caspase-like domain. Ginalski, K., Zhang, H., Grishin, N.V. Trends Biochem. Sci. (2004)
- Epornitic of avian pox in a raptor rehabilitation center. Wheeldon, E.B., Sedgwick, C.J., Schulz, T.A. J. Am. Vet. Med. Assoc. (1985)