Gene Review:
PTK6 - protein tyrosine kinase 6
Homo sapiens
Synonyms:
BRK, Breast tumor kinase, Protein-tyrosine kinase 6, Tyrosine-protein kinase BRK
- Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. Hong, E., Shin, J., Kim, H.I., Lee, S.T., Lee, W. J. Biol. Chem. (2004)
- Characterization of the 5'-flanking region of the human PTK6 gene. Kang, K.N., Kim, M., Pae, K.M., Lee, S.T. Biochim. Biophys. Acta (2002)
- Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. Easty, D.J., Mitchell, P.J., Patel, K., Flørenes, V.A., Spritz, R.A., Bennett, D.C. Int. J. Cancer (1997)
- BRK/Sik expression in the gastrointestinal tract and in colon tumors. Llor, X., Serfas, M.S., Bie, W., Vasioukhin, V., Polonskaia, M., Derry, J., Abbott, C.M., Tyner, A.L. Clin. Cancer Res. (1999)
- Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Derry, J.J., Prins, G.S., Ray, V., Tyner, A.L. Oncogene (2003)
- Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF. Chen, M.J., Holskin, B., Strickler, J., Gorniak, J., Clark, M.A., Johnson, P.J., Mitcho, M., Shalloway, D. Nature (1987)
- Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. Coyle, J.H., Guzik, B.W., Bor, Y.C., Jin, L., Eisner-Smerage, L., Taylor, S.J., Rekosh, D., Hammarskjöld, M.L. Mol. Cell. Biol. (2003)
- Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in Lymphocytes. Kasprzycka, M., Majewski, M., Wang, Z.J., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, M.R., Wasik, M.A. Am. J. Pathol. (2006)
- An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. Kim, H.I.e., Lee, S.T. J. Biol. Chem. (2005)
- Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. Lukong, K.E., Larocque, D., Tyner, A.L., Richard, S. J. Biol. Chem. (2005)
- Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Zhao, C., Yasui, K., Lee, C.J., Kurioka, H., Hosokawa, Y., Oka, T., Inazawa, J. Cancer (2003)
- Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain. Koo, B.K., Kim, M.H., Lee, S.T., Lee, W. J. Biochem. Mol. Biol. (2002)
- Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. Lee, H., Kim, M., Lee, K.H., Kang, K.N., Lee, S.T. Mol. Cells (1998)
- Regulated association of protein kinase B/Akt with breast tumor kinase. Zhang, P., Ostrander, J.H., Faivre, E.J., Olsen, A., Fitzsimmons, D., Lange, C.A. J. Biol. Chem. (2005)
- Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Kamalati, T., Jolin, H.E., Fry, M.J., Crompton, M.R. Oncogene (2000)
- Role of breast tumour kinase in the in vitro differentiation of HaCaT cells. Wang, T.C., Jee, S.H., Tsai, T.F., Huang, Y.L., Tsai, W.L., Chen, R.H. Br. J. Dermatol. (2005)
- A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. Mitchell, P.J., Sara, E.A., Crompton, M.R. Oncogene (2000)
- Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas. Born, M., Quintanilla-Fend, L., Braselmann, H., Reich, U., Richter, M., Hutzler, P., Aubele, M. J. Pathol. (2005)
- Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization. Park, S.H., Lee, K.H., Kim, H., Lee, S.T. Cytogenet. Cell Genet. (1997)
- Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium. Petro, B.J., Tan, R.C., Tyner, A.L., Lingen, M.W., Watanabe, K. Oral Oncol. (2004)