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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene: hand2
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heart and neural crest derivatives...
Danio rerio
Synonyms: Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dhand, dHAND, Heart-and neural crest derivatives-expressed protein 2, MGC103415, zdHAND, zgc:103415
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Using the zebrafishhand2 deletion mutant hands off, we have now investigated the physiological role of hand2 in the development of sympathetic ganglia[1].
First we show that edn1-expressing cells in the first (mandibular) and second (hyoid) pharyngeal arch primordia are located most ventrally and surrounded by hand2-expressing cells [2].
In hand2 mutants, bapx1 expression is present at the joint region, and expanded ventrally [2].
In addition, expression of eng2, normally restricted to first arch dorsal mesoderm, expands ventrally in hand2 and edn1 mutants [2].
Studies of mutants with morphogenetic defects have indicated at least six genes that are essential for cardiac fusion and heart tube assembly, including casanova, bonnie and clyde, gata5, one-eyed pinhead, hand2, miles apart, and heart and soul [3].
The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
