The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

RAD9A  -  RAD9 homolog A (S. pombe)

Homo sapiens

Synonyms: Cell cycle checkpoint control protein RAD9A, DNA repair exonuclease rad9 homolog A, hRAD9
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of RAD9A

 

High impact information on RAD9A

  • Microarray screening coupled with Northern analysis reveals that hRAD9 regulates the abundance of other messages in addition to p21 [3].
  • Using an electrophoretic mobility-shift assay, we show that hRAD9 specifically binds to a p53-consensus DNA-binding sequence in the p21 promoter [3].
  • It has been shown previously that, in vivo, a highly modified form of hRAD9 makes a ternary complex with two other checkpoint Rad proteins, hRAD1 and hHUS1 (Volkmer, E., and Karnitz, L. M. (1999) J. Biol. Chem. 274, 567-570; St. Onge, R. P., Udell, C. M., Casselman, R., and Davey, S. (1999) Mol. Biol. Cell. 10, 1985-1995) [1].
  • Our results suggest that exonucleolytic processing of primary DNA lesion by hRAD9 may contribute to DNA damage checkpoint response in humans [1].
  • Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease [1].
 

Biological context of RAD9A

 

Physical interactions of RAD9A

  • The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1 [4].
 

Other interactions of RAD9A

  • We demonstrate that overexpression of hRAD9 leads to increased p21 RNA and encoded protein levels [3].

References

  1. Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. Bessho, T., Sancar, A. J. Biol. Chem. (2000) [Pubmed]
  2. Induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells. Hayashi, K., Kuniyasu, H., Oue, N., Shigeishi, H., Kuraoka, K., Nakayama, H., Yasui, W. Pathobiology (2002) [Pubmed]
  3. Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21. Yin, Y., Zhu, A., Jin, Y.J., Liu, Y.X., Zhang, X., Hopkins, K.M., Lieberman, H.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. St Onge, R.P., Udell, C.M., Casselman, R., Davey, S. Mol. Biol. Cell (1999) [Pubmed]
  5. Determination of the genotype of a panel of human tumor cell lines for the human homologues of yeast cell cycle checkpoint control genes: identification of cell lines carrying homoallelic missense base substitutions. Ejima, Y., Yang, L. Somat. Cell Mol. Genet. (1999) [Pubmed]
 
WikiGenes - Universities