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Smpd3  -  sphingomyelin phosphodiesterase 3, neutral

Mus musculus

Synonyms: 4631433G07Rik, AI427456, AW537966, Neutral sphingomyelinase 2, Neutral sphingomyelinase II, ...
 
 
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Disease relevance of Smpd3

  • SMPD3 plays a pivotal role in the control of late embryonic and postnatal development: the smpd3-null mouse develops a novel form of dwarfism and delayed puberty as part of a hypothalamus-induced combined pituitary hormone deficiency [1].
  • Down-regulation of nSMase2 with siRNA largely prevented the dephosphorylation of the retinoblastoma protein and the induction of p21(WAF1), providing a link between the action of nSMase2 and key regulators of cell cycle progression [2].
 

High impact information on Smpd3

  • A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse [3].
  • Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development [1].
  • Neutral sphingomyelinases sphingomyelin phosphodiesterase (SMPD)2 and -3 hydrolyze sphingomyelin to phosphocholine and ceramide. smpd2 is expressed ubiquitously, and smpd3 is expressed predominantly in neurons of the CNS [1].
  • The role of endogenous nSMase2 in growth regulation and ceramide metabolism was investigated using short interfering RNA (siRNA)-mediated loss-of-function analysis [2].
  • Hence, we demonstrate for the first time that nSMase2 functions as a growth suppressor in MCF7 cells, linking confluence to the G(0)/G(1) cell cycle check point [2].
 

Biological context of Smpd3

 

Anatomical context of Smpd3

  • In contrast, nSMase2 became nearly exclusively located at the plasma membrane in confluent, contact-inhibited cells [2].
 

Associations of Smpd3 with chemical compounds

  • Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2 [5].
  • In this study, biochemical characterization of the mouse nSMase2 was carried out using the overexpressed protein in yeast cells in which the inositol phosphosphingolipid phospholipase C (Isc1p) was deleted [4].
 

Analytical, diagnostic and therapeutic context of Smpd3

References

  1. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Stoffel, W., Jenke, B., Blöck, B., Zumbansen, M., Koebke, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. Marchesini, N., Osta, W., Bielawski, J., Luberto, C., Obeid, L.M., Hannun, Y.A. J. Biol. Chem. (2004) [Pubmed]
  3. A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Aubin, I., Adams, C.P., Opsahl, S., Septier, D., Bishop, C.E., Auge, N., Salvayre, R., Negre-Salvayre, A., Goldberg, M., Guénet, J.L., Poirier, C. Nat. Genet. (2005) [Pubmed]
  4. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. Marchesini, N., Luberto, C., Hannun, Y.A. J. Biol. Chem. (2003) [Pubmed]
  5. Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2. Goswami, R., Ahmed, M., Kilkus, J., Han, T., Dawson, S.A., Dawson, G. J. Neurosci. Res. (2005) [Pubmed]
 
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