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Gene Review

RAP1B  -  RAP1B, member of RAS oncogene family

Homo sapiens

Synonyms: DKFZp586H0723, GTP-binding protein smg p21B, K-REV, OK/SW-cl.11, RAL1B, ...
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High impact information on RAP1B

  • In CHO-A(2A) cells, the stimulation of the A(2A)-receptor resulted in an activation of RAP1 and formation of RAP1-B-RAF complexes [1].
  • Three human cDNAs encoding new RAS-related cDNAs, designated RAP1A, RAP1B, and RAP2, have been isolated previously [2].
  • The three genes RAP1A, RAP1B, and RAP2 have been assigned to chromosome bands 1p12----p13, 12q14, and 13q34, respectively [2].

Biological context of RAP1B

  • Despite genomic polymorphism between strains, including sequences located within the open reading frame, defined RAP-1 B-cell surface epitopes and RAP-1 molecular size were conserved in both B. bovis and B. bigemina [3].


  1. MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases. Klinger, M., Kudlacek, O., Seidel, M.G., Freissmuth, M., Sexl, V. J. Biol. Chem. (2002) [Pubmed]
  2. Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively. Rousseau-Merck, M.F., Pizon, V., Tavitian, A., Berger, R. Cytogenet. Cell Genet. (1990) [Pubmed]
  3. Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism. Suarez, C.E., McElwain, T.F., Echaide, I., Torioni de Echaide, S., Palmer, G.H. Infect. Immun. (1994) [Pubmed]
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