Gene Review:
RBBP8 - retinoblastoma binding protein 8
Homo sapiens
Synonyms:
COM1, CTIP, CtBP-interacting protein, CtIP, DNA endonuclease RBBP8, ...
- Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Chen, P.L., Liu, F., Cai, S., Lin, X., Li, A., Chen, Y., Gu, B., Lee, E.Y., Lee, W.H. Mol. Cell. Biol. (2005)
- A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Meloni, A.R., Smith, E.J., Nevins, J.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- CtIP, a candidate tumor susceptibility gene is a team player with luminaries. Chinnadurai, G. Biochim. Biophys. Acta (2006)
- Peritoneal carcinomatosis: preoperative CT with intraperitoneal contrast material. Nelson, R.C., Chezmar, J.L., Hoel, M.J., Buck, D.R., Sugarbaker, P.H. Radiology. (1992)
- Effect of DNA damage on a BRCA1 complex. Wu-Baer, F., Baer, R. Nature (2001)
- BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Yu, X., Fu, S., Lai, M., Baer, R., Chen, J. Genes Dev. (2006)
- Molecular cloning and characterization of a novel retinoblastoma-binding protein. Fusco, C., Reymond, A., Zervos, A.S. Genomics (1998)
- Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. Yu, X., Baer, R. J. Biol. Chem. (2000)
- Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. Dubin, M.J., Stokes, P.H., Sum, E.Y., Williams, R.S., Valova, V.A., Robinson, P.J., Lindeman, G.J., Glover, J.N., Visvader, J.E., Matthews, J.M. J. Biol. Chem. (2004)
- Characterization of a carboxy-terminal BRCA1 interacting protein. Wong, A.K., Ormonde, P.A., Pero, R., Chen, Y., Lian, L., Salada, G., Berry, S., Lawrence, Q., Dayananth, P., Ha, P., Tavtigian, S.V., Teng, D.H., Bartel, P.L. Oncogene (1998)
- TRB3 interacts with CtIP and is overexpressed in certain cancers. Xu, J., Lv, S., Qin, Y., Shu, F., Xu, Y., Chen, J., Xu, B.E., Sun, X., Wu, J. Biochim. Biophys. Acta (2007)
- Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Varma, A.K., Brown, R.S., Birrane, G., Ladias, J.A. Biochemistry (2005)
- SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Germani, A., Prabel, A., Mourah, S., Podgorniak, M.P., Di Carlo, A., Ehrlich, R., Gisselbrecht, S., Varin-Blank, N., Calvo, F., Bruzzoni-Giovanelli, H. Oncogene (2003)
- Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. Koipally, J., Georgopoulos, K. J. Biol. Chem. (2002)
- DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Yu, X., Chen, J. Mol. Cell. Biol. (2004)
- The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. Sum, E.Y., Peng, B., Yu, X., Chen, J., Byrne, J., Lindeman, G.J., Visvader, J.E. J. Biol. Chem. (2002)
- Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. Sutherland, K.D., Visvader, J.E., Choong, D.Y., Sum, E.Y., Lindeman, G.J., Campbell, I.G. Int. J. Cancer (2003)