Gene Review:
TRPV4 - transient receptor potential cation...
Homo sapiens
Synonyms:
CMT2C, HMSN2C, OTRPC4, Osm-9-like TRP channel 4, SMAL, ...
- Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. Arniges, M., Vázquez, E., Fernández-Fernández, J.M., Valverde, M.A. J. Biol. Chem. (2004)
- WNK kinases influence TRPV4 channel function and localization. Fu, Y., Subramanya, A., Rozansky, D., Cohen, D.M. Am. J. Physiol. Renal Physiol. (2006)
- Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Lipski, J., Park, T.I., Li, D., Lee, S.C., Trevarton, A.J., Chung, K.K., Freestone, P.S., Bai, J.Z. Brain Res. (2006)
- Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Alvarez, D.F., King, J.A., Weber, D., Addison, E., Liedtke, W., Townsley, M.I. Circ. Res. (2006)
- The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. Wegierski, T., Hill, K., Schaefer, M., Walz, G. EMBO J. (2006)
- TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. Andrade, Y.N., Fernandes, J., Vázquez, E., Fernández-Fernández, J.M., Arniges, M., Sánchez, T.M., Villalón, M., Valverde, M.A. J. Cell Biol. (2005)
- Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Sidhaye, V.K., Güler, A.D., Schweitzer, K.S., D'Alessio, F., Caterina, M.J., King, L.S. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Vriens, J., Watanabe, H., Janssens, A., Droogmans, G., Voets, T., Nilius, B. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Transient receptor potential channels in endothelium: solving the calcium entry puzzle? Nilius, B., Droogmans, G., Wondergem, R. Endothelium (2003)
- Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. Strotmann, R., Schultz, G., Plant, T.D. J. Biol. Chem. (2003)
- PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco, M.P., Grimm, C., Oshima, K., D'hoedt, D., Nilius, B., Mensenkamp, A.R., Bindels, R.J., Plomann, M., Heller, S. J. Biol. Chem. (2006)
- TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. Liedtke, W. J. Physiol. (Lond.) (2005)
- Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Delany, N.S., Hurle, M., Facer, P., Alnadaf, T., Plumpton, C., Kinghorn, I., See, C.G., Costigan, M., Anand, P., Woolf, C.J., Crowther, D., Sanseau, P., Tate, S.N. Physiol. Genomics (2001)
- Warm temperatures activate TRPV4 in mouse 308 keratinocytes. Chung, M.K., Lee, H., Caterina, M.J. J. Biol. Chem. (2003)
- Functional TRPV4 channels are expressed in human airway smooth muscle cells. Jia, Y., Wang, X., Varty, L., Rizzo, C.A., Yang, R., Correll, C.C., Phelps, P.T., Egan, R.W., Hey, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- TRPV channels as temperature sensors. Benham, C.D., Gunthorpe, M.J., Davis, J.B. Cell Calcium (2003)
- Heat-evoked activation of the ion channel, TRPV4. Güler, A.D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., Caterina, M. J. Neurosci. (2002)
- Diversity of TRP channel activation. Nilius, B., Voets, T. Novartis Found. Symp. (2004)
- 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. Chung, M.K., Lee, H., Mizuno, A., Suzuki, M., Caterina, M.J. J. Neurosci. (2004)
- Bisandrographolide from Andrographis paniculata Activates TRPV4 Channels. Smith, P.L., Maloney, K.N., Pothen, R.G., Clardy, J., Clapham, D.E. J. Biol. Chem. (2006)
- Molecular determinants of permeation through the cation channel TRPV4. Voets, T., Prenen, J., Vriens, J., Watanabe, H., Janssens, A., Wissenbach, U., Bödding, M., Droogmans, G., Nilius, B. J. Biol. Chem. (2002)
- Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. Wegierski, T., Lewandrowski, U., Müller, B., Sickmann, A., Walz, G. J. Biol. Chem. (2009)
- OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. Wang, Y., Fu, X., Gaiser, S., Köttgen, M., Kramer-Zucker, A., Walz, G., Wegierski, T. J. Biol. Chem. (2007)
- Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T., Nilius, B. Nature (2003)
- TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Vriens, J., Janssens, A., Prenen, J., Nilius, B., Wondergem, R. Cell Calcium (2004)
- A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. Liu, X., Bandyopadhyay, B., Nakamoto, T., Singh, B., Liedtke, W., Melvin, J.E., Ambudkar, I. J. Biol. Chem. (2006)
- Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. Xu, H., Zhao, H., Tian, W., Yoshida, K., Roullet, J.B., Cohen, D.M. J. Biol. Chem. (2003)