Disease relevance of Fgf5

• Furthermore, FGF-5, when infused into the third ventricle, consistently reduced food intake, water intake and body weight gain, all in a dose-dependent manner [1].

Psychiatry related information on Fgf5

• These results suggest that FGF-5 in the hypothalamus acts as a physiological regulator of feeding behaviour, and that its decreased expression during food deprivation may be important in stimulating appetite [1].

High impact information on Fgf5

• In some cases, normal or irradiation-treated pups were intraocularly injected with FGF 5 d prior to the fiber count in order to promote neurite outgrowth [2].
• The investigation was extended to other members of the FGF family, such as FGF-5 and -20, but this expression was not influenced by the (-)nicotine treatment at any age studied [3].
• FGF-5 specifically affects mesencephalic astroglial cells without changing coupling of cortical and striatal astroglia, while FGF-9 reduces gap junctional coupling in astroglia from all three brain regions [4].
• We show that both FGF-5 and FGF-9, like FGF-2, downregulate astroglial gap junctions and functional coupling [4].
• Staining of the rat skin revealed that only the B2B6 antibody reacted with hair follicles and that both antibodies reacted with macrophage-like round cells, suggesting that the product of the Fgf-5 gene in the hair follicle is FGF-5S [5].

Biological context of Fgf5

• The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5 [6].
• The rat FGF-5 gene consists of three exons (exons 1-3) [6].
• Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells [7].
• Possible coordinated gene expressions for FGF receptor, FGF-5, and FGF-2 following seizures [8].
• We show that FGF1, FGF4, and FGF6 (as well as hepatocyte growth factor, HGF) enhance satellite cell proliferation to a similar degree as that seen with FGF2, whereas FGF5 and FGF7 are ineffective [9].

Anatomical context of Fgf5

• In the present study, DPCs and ORSCs were isolated from rat vibrissae, after which the effects of FGF-5 on proliferation of ORSCs cultured in DPC-conditioned medium were assessed [10].
• Thus, the results suggest the possible involvement of FGF-5S in the hair follicle in anagen VI and catagen development and that the density of FGF-5-positive macrophage-like cells may also be associated with the hair growth cycle [5].
• The density of FGF-5-positive macrophage-like cells in the dermis increased during anagen and decreased during catagen and telogen, whereas the density of these cells in the panniculus adiposus did not change during anagen and increased during catagen and telogen [5].
• Distribution of fibroblast growth factor-5 in rat hypothalamus, and its possible role as a regulator of feeding behaviour [1].
• We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family [7].

Associations of Fgf5 with chemical compounds

• Epileptiform activity was induced by kainic acid injection, and in situ hybridization was used to assess the progress of changes in distribution and intensities of FGF receptor 1 (FGFR-1), FGF-5, and FGF-2 mRNAs [8].

Other interactions of Fgf5

• Transforming growth factor beta-1 and glial cell line-derived neurotrophic factor were less potent, while fibroblast growth factor-5 was only marginally effective [11].
• These results demonstrate that brain activity exerts influences at the gene expression levels of FGFR-1 and its ligands FGF-5 and FGF-2 [8].
• The primary olfactory cortex also showed a robust expression of FGF-5 mRNA mostly within layer II [12].
• The temporal sequence of FGF-5 mRNA expression was similar to that of FGFR-4 mRNA expression [13].
• FGF-5 is a newly described member of the fibroblast growth factor family [12].

Analytical, diagnostic and therapeutic context of Fgf5

• Two monoclonal anti-FGF-5 antibodies, one (E723) being specific for FGF-5 long-form protein and the other (B2B6) being reactive with both FGF-5 and FGF-5S proteins, were used to locate these proteins by immunohistochemistry [5].
• This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve [7].
• FGF-2 and FGF-6 mRNA levels decreased significantly following denervation; however, FGF-1, FGF-5, FGF-7 and HGF mRNA levels increased and maintained this increase for the 21-days treatment period [14].

References