Gene Review:
ROBO1 - roundabout, axon guidance receptor,...
Homo sapiens
Synonyms:
DUTT1, Deleted in U twenty twenty, FLJ21882, H-Robo-1, Roundabout homolog 1, ...
Gröne,
Doebler,
Loddenkemper,
Hotz,
Buhr,
Bhargava,
Narayan,
Goparaju,
Arias-Pulido,
Kaufmann,
Schneider,
Dürst,
Mansukhani,
Pothuri,
Murty,
- Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Ito, H., Funahashi, S., Yamauchi, N., Shibahara, J., Midorikawa, Y., Kawai, S., Kinoshita, Y., Watanabe, A., Hippo, Y., Ohtomo, T., Iwanari, H., Nakajima, A., Makuuchi, M., Fukayama, M., Hirata, Y., Hamakubo, T., Kodama, T., Tsuchiya, M., Aburatani, H. Clin. Cancer Res. (2006)
- Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. Prasad, A., Fernandis, A.Z., Rao, Y., Ganju, R.K. J. Biol. Chem. (2004)
- Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. Dallol, A., Forgacs, E., Martinez, A., Sekido, Y., Walker, R., Kishida, T., Rabbitts, P., Maher, E.R., Minna, J.D., Latif, F. Oncogene (2002)
- Homozygous deletions at 3p12 in breast and lung cancer. Sundaresan, V., Chung, G., Heppell-Parton, A., Xiong, J., Grundy, C., Roberts, I., James, L., Cahn, A., Bench, A., Douglas, J., Minna, J., Sekido, Y., Lerman, M., Latif, F., Bergh, J., Li, H., Lowe, N., Ogilvie, D., Rabbitts, P. Oncogene (1998)
- The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. Hannula-Jouppi, K., Kaminen-Ahola, N., Taipale, M., Eklund, R., Nopola-Hemmi, J., Kääriäinen, H., Kere, J. PLoS Genet. (2005)
- Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Wong, K., Ren, X.R., Huang, Y.Z., Xie, Y., Liu, G., Saito, H., Tang, H., Wen, L., Brady-Kalnay, S.M., Mei, L., Wu, J.Y., Xiong, W.C., Rao, Y. Cell (2001)
- Regulation of commissural axon pathfinding by slit and its robo receptors. Dickson, B.J., Gilestro, G.F. Annu. Rev. Cell Dev. Biol. (2006)
- Son of sevenless directly links the robo receptor to rac activation to control axon repulsion at the midline. Yang, L., Bashaw, G.J. Neuron (2006)
- Generating X: formation of the optic chiasm. Rasband, K., Hardy, M., Chien, C.B. Neuron (2003)
- Downstream of guidance receptors: entering the baroque period of axon guidance signaling. Schmucker, D. Neuron (2003)
- SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Dallol, A., Da Silva, N.F., Viacava, P., Minna, J.D., Bieche, I., Maher, E.R., Latif, F. Cancer Res. (2002)
- Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005)
- Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Narayan, G., Goparaju, C., Arias-Pulido, H., Kaufmann, A.M., Schneider, A., Dürst, M., Mansukhani, M., Pothuri, B., Murty, V.V. Mol. Cancer (2006)
- Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. Hivert, B., Liu, Z., Chuang, C.Y., Doherty, P., Sundaresan, V. Mol. Cell. Neurosci. (2002)
- Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Xian, J., Aitchison, A., Bobrow, L., Corbett, G., Pannell, R., Rabbitts, T., Rabbitts, P. Cancer Res. (2004)
- Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice. Yue, Y., Grossmann, B., Galetzka, D., Zechner, U., Haaf, T. Genomics (2006)
- Frequent epigenetic inactivation of the SLIT2 gene in gliomas. Dallol, A., Krex, D., Hesson, L., Eng, C., Maher, E.R., Latif, F. Oncogene (2003)
- Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. Jia, L., Cheng, L., Raper, J. Dev. Biol. (2005)
- Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Xian, J., Clark, K.J., Fordham, R., Pannell, R., Rabbitts, T.H., Rabbitts, P.H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. Hussain, S.A., Piper, M., Fukuhara, N., Strochlic, L., Cho, G., Howitt, J.A., Ahmed, Y., Powell, A.K., Turnbull, J.E., Holt, C.E., Hohenester, E. J. Biol. Chem. (2006)
- Neuronal clues to vascular guidance. Suchting, S., Bicknell, R., Eichmann, A. Exp. Cell Res. (2006)
- The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Yuan, W., Zhou, L., Chen, J.H., Wu, J.Y., Rao, Y., Ornitz, D.M. Dev. Biol. (1999)
- Inhibition of medulloblastoma cell invasion by Slit. Werbowetski-Ogilvie, T.E., Seyed Sadr, M., Jabado, N., Angers-Loustau, A., Agar, N.Y., Wu, J., Bjerkvig, R., Antel, J.P., Faury, D., Rao, Y., Del Maestro, R.F. Oncogene (2006)
- Slit2 is a repellent for retinal ganglion cell axons. Niclou, S.P., Jia, L., Raper, J.A. J. Neurosci. (2000)
- Robo1/Robo4: Differential expression of angiogenic markers in colorectal cancer. Gröne, J., Doebler, O., Loddenkemper, C., Hotz, B., Buhr, H.J., Bhargava, S. Oncol. Rep. (2006)
- Expression and role of Roundabout-1 in embryonic Xenopus forebrain. Connor, R.M., Key, B. Dev. Dyn. (2002)
- Comparison of recording systems and analysis methods in specular microscopy. Ohno, K., Nelson, L.R., McLaren, J.W., Hodge, D.O., Bourne, W.M. Cornea (1999)