Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RPL13 - ribosomal protein L13

Homo sapiens

Synonyms: 60S ribosomal protein L13, BBC1, Breast basic conserved protein 1, D16S444E, FLJ27453, ...

Cleton-Jansen, A.M. et al., Moerland, E. et al., Lee, A.Y. et al., Kobayashi, T. et al., Franco, G.R. et al., et al.

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Disease relevance of RPL13

The absence of tumour-specific mutations in CMAR and BBC1 in this selected series of breast tumours implies that another gene at 16q24.3 must be the tumour-suppressor gene that is the target for LOH in breast cancer [1].
Activation of the ribosomal protein L13 gene in human gastrointestinal cancer [2].

High impact information on RPL13

In addition, reduced RNA expression of two other genes at 8E1 encoding COX4I1 and RPL13 could be explained by a decrease in chromosomal copy number on chromosome 8 [3].
In the BBC1 gene, three different alterations were found, but only one resulted in an amino acid substitution [1].
Expression levels were restored to normal particularly in four types of mRNAs, which were matched with sequences encoding eukaryotic translation initiation factor 4A1 (eIF4A1), ribosomal protein L13, mediator of RNA polymerase to transcription (MRT) and ribosomal phosphoprotein PO [4].
In our earlier study, we showed that ribosomal protein L13 mRNA was up-regulated in response to DNA damage in hamster cells [2].
We show that the D16S444E gene is localized on band 16q24.3 and is located between APRT and D16S44 [5].

Biological context of RPL13

Mapping of the breast basic conserved gene (D16S444E) to human chromosome band 16q24.3 [5].
The breast basic conserved gene (D16S444E) is a candidate tumor suppressor gene previously mapped to human chromosome 16 [5].
We determined the map position of D16S444E more precisely using a somatic mouse x human hybrid panel and fluorescence in situ hybridization on metaphase spreads and interphase nuclei [5].
The Schistosoma mansoni gene sequence encoding the breast basic conserved protein 1/ribosomal protein L13 has been isolated from an adult worm cDNA library using the Expressed Sequence Tag strategy [6].

References

Exclusion of BBC1 and CMAR as candidate breast tumour-suppressor genes. Moerland, E., Breuning, M.H., Cornelisse, C.J., Cleton-Jansen, A.M. Br. J. Cancer (1997)
Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. Kobayashi, T., Sasaki, Y., Oshima, Y., Yamamoto, H., Mita, H., Suzuki, H., Toyota, M., Tokino, T., Itoh, F., Imai, K., Shinomura, Y. Int. J. Mol. Med. (2006)
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations. van de Wiel, M.A., Costa, J.L., Smid, K., Oudejans, C.B., Bergman, A.M., Meijer, G.A., Peters, G.J., Ylstra, B. Cancer Res. (2005)
All trans-retinoic acid (ATRA) elevated eukaryotic translation initiation factor 4A1 (eIF4A1) mRNA in ATRA-responsive vitiliginous epidermis. Lee, A.Y., Kim, N.H., Park, S.W. Pigment Cell Res. (2004)
Mapping of the breast basic conserved gene (D16S444E) to human chromosome band 16q24.3. Cleton-Jansen, A.M., Moerland, H.W., Callen, D.F., Doggett, N.A., Devilee, P., Cornelisse, C.J. Cytogenet. Cell Genet. (1995)
Characterization of a Schistosoma mansoni homologue of the gene encoding the breast basic conserved protein 1/L13 ribosomal protein. Franco, G.R., Tanaka, M., Simpson, A.J., Pena, S.D. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998)

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PF08_0075	Plasmodium falciparum 3D7
Os06g0115500	Oryza sativa Japonica Group
Os03g0576700	Oryza sativa Japonica Group
ATBBC1	Arabidopsis thaliana
AT5G23900	Arabidopsis thaliana
NCU05554	Neurospora crassa OR74A
MGG_09769	Magnaporthe oryzae 70-15
MGG_13645	Magnaporthe oryzae 70-15
AGOS_ADR257C	Ashbya gossypii ATCC 10895
KLLA0E22099g	Kluyveromyces lactis NRRL Y-1140
RPL13A	Saccharomyces cerevisiae S288c
RPL13B	Saccharomyces cerevisiae S288c
rpl13	Schizosaccharomyces pombe
rpl-13	Caenorhabditis elegans
AgaP_AGAP001805	Anopheles gambiae str. PEST
RpL13	Drosophila melanogaster
rpl13	Danio rerio
RPL13	Gallus gallus
Rpl13	Rattus norvegicus
Rpl13-ps3	Mus musculus
RPL13	Bos taurus
RPL13	Canis lupus familiaris
RPL13	Pan troglodytes

RPL13 - ribosomal protein L13

Homo sapiens

Disease relevance of RPL13

High impact information on RPL13

Biological context of RPL13

References

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