Disease relevance of RPS20

• We demonstrate that gain of 8q and expression levels of three 8q-mapped candidate genes (EEF1D, RPL30, RPS20) are associated with adverse outcome in medulloblastoma [1].
• Conserved amino acid residues in the primary structure of ribosomal protein S20 from selected gram-negative bacteria [2].

High impact information on RPS20

• Directed hydroxyl radical probing of 16S ribosomal RNA in ribosomes containing Fe(II) tethered to ribosomal protein S20 [3].
• We found a rice genomic segment where two genes, encoding 5-enolpyruvylshikimate-3-phosphate synthase (EPSPs) and ribosomal protein small subunit 20 (rps20), are located in a tail-to-tail orientation and separated by only 300 bp of spacer [4].
• Isolation of a cDNA clone, encoding the ribosomal protein S20, downregulated during the onset of apoptosis in a human leukaemic cell line [5].
• Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8 [1].
• Partial DNA sequences encoding ribosomal protein S20 have been determined for a number of Gram-negative bacteria including three species of Aeromonas, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella typhimurium and compared to the known sequence from Escherichia coli [2].

Anatomical context of RPS20

• The 16S ribosomal RNA neighborhood of ribosomal protein S20 has been mapped, in both 30S subunits and 70S ribosomes, using directed hydroxyl radical probing [3].

References