Gene Review:
BHMT - betaine--homocysteine S-methyltransferase
Homo sapiens
Synonyms:
BHMT1, Betaine--homocysteine S-methyltransferase 1, HEL-S-61p
- Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? Zhu, H., Curry, S., Wen, S., Wicker, N.J., Shaw, G.M., Lammer, E.J., Yang, W., Jafarov, T., Finnell, R.H. Am. J. Med. Genet. A (2005)
- Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. Garrow, T.A. J. Biol. Chem. (1996)
- Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans. Heil, S.G., Lievers, K.J., Boers, G.H., Verhoef, P., den Heijer, M., Trijbels, F.J., Blom, H.J. Mol. Genet. Metab. (2000)
- Synthesis of betaine-homocysteine S-methyltransferase is continuously enhanced in fatty livers of thyroidectomized chickens. Shibata, T., Akamine, T., Nikki, T., Yamashita, H., Nobukuni, K. Poult. Sci. (2003)
- Homocysteine metabolism in ZDF (type 2) diabetic rats. Wijekoon, E.P., Hall, B., Ratnam, S., Brosnan, M.E., Zeisel, S.H., Brosnan, J.T. Diabetes (2005)
- Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. Park, E.I., Garrow, T.A. J. Biol. Chem. (1999)
- Expression of recombinant human betaine: homocysteine S-methyltransferase for x-ray crystallographic studies and further characterization of interaction with S-adenosylmethionine. Bose, N., Greenspan, P., Momany, C. Protein Expr. Purif. (2002)
- Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene. Neece, D.J., Griffiths, M.A., Garrow, T.A. Gene (2000)
- Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Boyles, A.L., Billups, A.V., Deak, K.L., Siegel, D.G., Mehltretter, L., Slifer, S.H., Bassuk, A.G., Kessler, J.A., Reed, M.C., Nijhout, H.F., George, T.M., Enterline, D.S., Gilbert, J.R., Speer, M.C. Environ. Health Perspect. (2006)
- Genetic linkage of candidate genes in families with abdominal aortic aneurysms? van Vlijmen-van Keulen, C.J., Vahl, A.C., Hennekam, R.C., Rauwerda, J.A., Pals, G. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2003)
- Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Weisberg, I.S., Park, E., Ballman, K.V., Berger, P., Nunn, M., Suh, D.S., Breksa, A.P., Garrow, T.A., Rozen, R. Atherosclerosis (2003)
- Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney. Delgado-Reyes, C.V., Wallig, M.A., Garrow, T.A. Arch. Biochem. Biophys. (2001)
- Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Sunden, S.L., Renduchintala, M.S., Park, E.I., Miklasz, S.D., Garrow, T.A. Arch. Biochem. Biophys. (1997)
- Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Chadwick, L.H., McCandless, S.E., Silverman, G.L., Schwartz, S., Westaway, D., Nadeau, J.H. Genomics (2000)
- Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Castro, C., Gratson, A.A., Evans, J.C., Jiracek, J., Collinsová, M., Ludwig, M.L., Garrow, T.A. Biochemistry (2004)
- Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Breksa, A.P., Garrow, T.A. Arch. Biochem. Biophys. (2002)
- Hepatic transmethylation and blood alcohol levels. Barak, A.J., Beckenhauer, H.C., Tuma, D.J. Alcohol Alcohol. (1991)
- Homocysteine catabolism: levels of 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease. Wang, J., Dudman, N.P., Wilcken, D.E., Lynch, J.F. Atherosclerosis (1992)
- Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. Slow, S., Garrow, T.A. J. Nutr. (2006)
- Common genetic polymorphisms affect the human requirement for the nutrient choline. da Costa, K.A., Kozyreva, O.G., Song, J., Galanko, J.A., Fischer, L.M., Zeisel, S.H. FASEB J. (2006)
- Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. Liang, C.R., Leow, C.K., Neo, J.C., Tan, G.S., Lo, S.L., Lim, J.W., Seow, T.K., Lai, P.B., Chung, M.C. Proteomics (2005)
- Crystallization and preliminary X-ray crystallographic studies of recombinant human betaine-homocysteine S-methyltransferase. Bose N, n.u.l.l., Momany C, n.u.l.l. Acta Crystallogr. D Biol. Crystallogr. (2001)