Gene Review:
CCL8 - chemokine (C-C motif) ligand 8
Homo sapiens
Synonyms:
C-C motif chemokine 8, HC14, MCP-2, MCP2, Monocyte chemoattractant protein 2, ...
- Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hellier, S., Frodsham, A.J., Hennig, B.J., Klenerman, P., Knapp, S., Ramaley, P., Satsangi, J., Wright, M., Zhang, L., Thomas, H.C., Thursz, M., Hill, A.V. Hepatology (2003)
- Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication. Gong, W., Howard, O.M., Turpin, J.A., Grimm, M.C., Ueda, H., Gray, P.W., Raport, C.J., Oppenheim, J.J., Wang, J.M. J. Biol. Chem. (1998)
- Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV. Van Coillie, E., Proost, P., Van Aelst, I., Struyf, S., Polfliet, M., De Meester, I., Harvey, D.J., Van Damme, J., Opdenakker, G. Biochemistry (1998)
- Patterns of protein expression in infectious meningitis: a cerebrospinal fluid protein array analysis. Kastenbauer, S., Angele, B., Sporer, B., Pfister, H.W., Koedel, U. J. Neuroimmunol. (2005)
- Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. Yang, O.O., Garcia-Zepeda, E.A., Walker, B.D., Luster, A.D. J. Infect. Dis. (2002)
- HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Izmailova, E., Bertley, F.M., Huang, Q., Makori, N., Miller, C.J., Young, R.A., Aldovini, A. Nat. Med. (2003)
- Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. Taub, D.D., Proost, P., Murphy, W.J., Anver, M., Longo, D.L., van Damme, J., Oppenheim, J.J. J. Clin. Invest. (1995)
- TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. Secchiero, P., Corallini, F., di Iasio, M.G., Gonelli, A., Barbarotto, E., Zauli, G. Blood (2005)
- Multiple nonfunctional alleles of CCR5 are frequent in various human populations. Blanpain, C., Lee, B., Tackoen, M., Puffer, B., Boom, A., Libert, F., Sharron, M., Wittamer, V., Vassart, G., Doms, R.W., Parmentier, M. Blood (2000)
- Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Bossink, A.W., Paemen, L., Jansen, P.M., Hack, C.E., Thijs, L.G., Van Damme, J. Blood (1995)
- Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors. Gong, X., Gong, W., Kuhns, D.B., Ben-Baruch, A., Howard, O.M., Wang, J.M. J. Biol. Chem. (1997)
- The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. Van Coillie, E., Fiten, P., Nomiyama, H., Sakaki, Y., Miura, R., Yoshie, O., Van Damme, J., Opdenakker, G. Genomics (1997)
- Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. Franci, C., Wong, L.M., Van Damme, J., Proost, P., Charo, I.F. J. Immunol. (1995)
- Monocyte chemotactic protein-2, monocyte chemotactic protein-3, and fibroblast-induced cytokine. Three new chemokines induce chemotaxis and activation of basophils. Alam, R., Forsythe, P., Stafford, S., Heinrich, J., Bravo, R., Proost, P., Van Damme, J. J. Immunol. (1994)
- Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. Weber, M., Uguccioni, M., Ochensberger, B., Baggiolini, M., Clark-Lewis, I., Dahinden, C.A. J. Immunol. (1995)
- Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2. O'boyle, G., Brain, J.G., Kirby, J.A., Ali, S. Mol. Immunol. (2007)
- Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. Sozzani, S., Zhou, D., Locati, M., Rieppi, M., Proost, P., Magazin, M., Vita, N., van Damme, J., Mantovani, A. J. Immunol. (1994)
- Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells. Van Coillie, E., Froyen, G., Nomiyama, H., Miura, R., Fiten, P., Van Aelst, I., Van Damme, J., Opdenakker, G. Biochem. Biophys. Res. Commun. (1997)
- Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2. Richardson, R.M., Pridgen, B.C., Haribabu, B., Snyderman, R. J. Biol. Chem. (2000)
- Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. Blaszczyk, J., Coillie, E.V., Proost, P., Damme, J.V., Opdenakker, G., Bujacz, G.D., Wang, J.M., Ji, X. Biochemistry (2000)
- Monocyte chemoattractant protein-2 can exert its effects through the MCP-1 receptor (CC CKR2B). Yamagami, S., Tanaka, H., Endo, N. FEBS Lett. (1997)
- Monocyte chemoattractant protein-2 is a potent agonist of CCR2B. Moore, U.M., Kaplow, J.M., Pleass, R.D., Castro, S.W., Naik, K., Lynch, C.N., Daly, S., Roach, A.G., Jaye, M., Williams, R.J. J. Leukoc. Biol. (1997)
- Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers. Chemical synthesis of MCP-2 and development of a specific RIA. Van Damme, J., Proost, P., Put, W., Arens, S., Lenaerts, J.P., Conings, R., Opdenakker, G., Heremans, H., Billiau, A. J. Immunol. (1994)