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NECAB3  -  N-terminal EF-hand calcium binding protein 3

Homo sapiens

Synonyms: APBA2BP, Amyloid beta A4 protein-binding family A member 2-binding protein, EFCBP3, N-terminal EF-hand calcium-binding protein 3, NIP1, ...
 
 
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High impact information on APBA2BP

  • Here, we describe the molecular characterization of a novel human centrosomal protein, C-Nap1 (for centrosomal Nek2-associated protein 1), first identified as a Nek2-interacting protein in a yeast two-hybrid screen [1].
  • Solution structure of the plant disease resistance-triggering protein NIP1 from the fungus Rhynchosporium secalis shows a novel beta-sheet fold [2].
  • XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms [3].
  • The virulence of the NIP1 types was tested on Rrs1 and rrs1 barley lines [4].
  • In addition, we found that EFCBP1, EFCBP2 and EFCBP3 share a similar exon distribution mode, though their chromosomal localizations, genomic sizes and intron sizes are diverse [5].
 

Biological context of APBA2BP

  • Human EFCBP1 encodes a 351 amino acid protein containing two EF-hand motifs and an antibiotic biosynthesis monooxygenase (ABM) domain, sharing 49.9 and 56.8% global homology with human EFCBP2 and EFCBP3 [5].

References

  1. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. Fry, A.M., Mayor, T., Meraldi, P., Stierhof, Y.D., Tanaka, K., Nigg, E.A. J. Cell Biol. (1998) [Pubmed]
  2. Solution structure of the plant disease resistance-triggering protein NIP1 from the fungus Rhynchosporium secalis shows a novel beta-sheet fold. van't Slot, K.A., van den Burg, H.A., Kloks, C.P., Hilbers, C.W., Knogge, W., Papavoine, C.H. J. Biol. Chem. (2003) [Pubmed]
  3. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Sumioka, A., Imoto, S., Martins, R.N., Kirino, Y., Suzuki, T. Biochem. J. (2003) [Pubmed]
  4. Molecular population genetic analysis differentiates two virulence mechanisms of the fungal avirulence gene NIP1. Schürch, S., Linde, C.C., Knogge, W., Jackson, L.F., McDonald, B.A. Mol. Plant Microbe Interact. (2004) [Pubmed]
  5. EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains. Wu, H., Li, D., Shan, Y., Wan, B., Hexige, S., Guo, J., Wu, C., Yu, L. DNA Seq. (2007) [Pubmed]
 
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