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Gene Review

SRSF3  -  serine/arginine-rich splicing factor 3

Homo sapiens

Synonyms: Pre-mRNA-splicing factor SRP20, SFRS3, SRP20, SRp20, Serine/arginine-rich splicing factor 3, ...
 
 
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Disease relevance of SFRS3

  • We identified a novel t(3;6)(q27;p21) in a follicular lymphoma (FL) with histologic evidence of transformation and, by cloning the translocation junction, determined that the SRP20 gene was the partner [1].
 

High impact information on SFRS3

 

Biological context of SFRS3

 

Associations of SFRS3 with chemical compounds

  • Identification of a pre-mRNA splicing factor, arginine/serine-rich 3 (Sfrs3), and its co-expression with fibronectin in fetal and postnatal rabbit airway mucosal and skin wounds [3].

References

  1. Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma. Chen, W., Itoyama, T., Chaganti, R.S. Genes Chromosomes Cancer (2001) [Pubmed]
  2. CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Tai, H.H., Geisterfer, M., Bell, J.C., Moniwa, M., Davie, J.R., Boucher, L., McBurney, M.W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Identification of a pre-mRNA splicing factor, arginine/serine-rich 3 (Sfrs3), and its co-expression with fibronectin in fetal and postnatal rabbit airway mucosal and skin wounds. Li-Korotky, H.S., Hebda, P.A., Kelly, L.A., Lo, C.Y., Dohar, J.E. Biochim. Biophys. Acta (2005) [Pubmed]
 
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