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Gene: Rpl24  -  ribosomal protein L24

Rattus norvegicus

Synonyms: 60S ribosomal protein L24, L30
 
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Disease relevance of Rpl24

  • There are indications that a segment of 23 residues in rat L19 is related to sequences of the same length in Escherichia coli ribosomal proteins L30, L18, and S2 [1].
  • Rat L7 appears to be related to ribosomal protein L7 from the moderate halophile Vibrio costicola and perhaps to L30 from Bacillus stearothermophilus, to L7 from the moderate halophile NRCC 41227, and to L22 from Nicotinia tobaccum chloroplast [2].
 

High impact information on Rpl24

  • 5. Seventeen proteins (L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39) were isolated from three of the groups (B60, D60, G60) by ion exchange chromatography on carboxymethylcellulose and by filtration through Sephadex [3].
  • The aa sequence of L30 protein was deduced from the nucleotide sequence of the cDNA [4].
  • cDNA clones coding for rat liver ribosomal proteins S17 and L30 have been isolated by positive hybridization-translation assay from a cDNA library prepared from 8-9S poly(A)+RNA from free polysomes of regenerating rat liver [4].
  • The cDNA showed twelve silent changes in the coding region, one point mutation and one base deletion in the 3'-noncoding region, compared with mouse genomic DNA for L30 protein [Wiedemann and Perry, Mol. Cell Biol. 4 (1984) 2518-2528] [4].
  • Proteins S18, S20, S28 and L5, L9, L11, L15, L16, L25, L29, L30, L31, L34, L37 have NH2 groups exposed in native subunits [5].
 

Biological context of Rpl24

  • We propose a model in which SBP2 and L30 carry out different functions in the UGA recoding mechanism, with the SECIS acting as a molecular switch upon protein binding [6].

References

  1. The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. Chan, Y.L., Lin, A., McNally, J., Peleg, D., Meyuhas, O., Wool, I.G. J. Biol. Chem. (1987)
  2. The primary structure of rat ribosomal protein L7. The presence near the amino terminus of L7 of five tandem repeats of a sequence of 12 amino acids. Lin, A., Chan, Y.L., McNally, J., Peleg, D., Meyuhas, O., Wool, I.G. J. Biol. Chem. (1987)
  3. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. Tsurugi, K., Collatz, E., Wool, E.G., Lin, A. J. Biol. Chem. (1976)
  4. Molecular cloning and nucleotide sequences of cDNAs specific for rat liver ribosomal proteins S17 and L30. Nakanishi, O., Oyanagi, M., Kuwano, Y., Tanaka, T., Nakayama, T., Mitsui, H., Nabeshima, Y., Ogata, K. Gene (1985)
  5. Study of mammalian ribosomal protein reactivity in situ. I. - Effect of 2-methoxy-5-nitrotropone on 40S and 60S subunits. Reboud, A.M., Madjar, J.J., Buisson, M., Reboud, J.J. Biochimie (1975)
  6. Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes. Chavatte, L., Brown, B.A., Driscoll, D.M. Nat. Struct. Mol. Biol. (2005)
 
 
 
 
 
 
 
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