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Gene Review: 

Csnk1d  -  casein kinase 1, delta

Rattus norvegicus

Synonyms: CKI-delta, Casein kinase I isoform delta, Hckid, Tau-protein kinase CSNK1D
 
 
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Disease relevance of Csnk1d

  • A truncation mutant of CKI delta lacking the C-terminal autoinhibitory region was expressed in Escherichia coli, purified, and crystallized [1].
 

High impact information on Csnk1d

  • Here we report that casein kinases I epsilon and delta (CKI epsilon and CKI delta), the crucial clock regulators, form a complex with GABA(A) receptors and inhibit the receptors' function within the SCN according to a circadian rhythm [2].
  • The three-dimensional structure for the catalytic region of the mammalian protein kinase, casein kinase I delta (CKI delta), has been solved by X-ray crystallography to a resolution of 2.3 A [1].

References

  1. Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition. Longenecker, K.L., Roach, P.J., Hurley, T.D. J. Mol. Biol. (1996) [Pubmed]
  2. Circadian regulation of GABAA receptor function by CKI epsilon-CKI delta in the rat suprachiasmatic nuclei. Ning, K., Li, L., Liao, M., Liu, B., Mielke, J.G., Chen, Y., Duan, Y., El-Hayek, Y.H., Wan, Q. Nat. Neurosci. (2004) [Pubmed]
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