Disease relevance of Wnt5a

• However, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express Wnt-5a, thus promoting their potential for dopaminergic differentiation [1].

High impact information on Wnt5a

• 5) E2 activated the expression of the Wnt-5a and Wnt-7a ligands, and at the same time, E2, through the alpha-estrogen receptor, was able to prevent the excitotoxic A beta-induced rise in bulk-free Ca2+ as an alternative pathway to increase cell viability [2].
• Ablation of Wnt5a by antisense cDNA inhibited LIF-induced cell adhesion [3].
• Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes [3].
• Wnt-5a expression in the rat neuronal progenitor cell line ST14A [1].
• Wnt5a and Wnt6 expression was higher in PC12/Wnt1 cells than in PC12 or PC12/flat [4].

Biological context of Wnt5a

• Rat Wnt5a and Wnt5b genes, consisting of five exons, were identified within AC095764.5 and AC112027.3 genome sequences, respectively [5].
• Rat Wnt5a (380 aa) and Wnt5b (359 aa) were secreted proteins with 24 conserved Cys residues and four Asn-linked glycosylation sites, which showed 75.8% total-amino-acid identity [5].
• For the first time, we found endogenous Wnt-5a, a regulator molecule that can induce dopaminergic phenotype, by RT-PCR, Western blot and flow cytometry in the neuronal progenitor cell line ST14A and its derivatives CNTF-ST14A and GDNF-ST14A [1].

References