Gene Review:
SIAH1 - siah E3 ubiquitin protein ligase 1
Homo sapiens
Synonyms:
E3 ubiquitin-protein ligase SIAH1, HUMSIAH, Seven in absentia homolog 1, Siah-1, Siah-1a, ...
- Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C.A., Rott, R., Engelender, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas. Matsuo, K., Satoh, S., Okabe, H., Nomura, A., Maeda, T., Yamaoka, Y., Ikai, I. Genes Chromosomes Cancer (2003)
- Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia. Simon, M.C. Cell (2004)
- Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells. Jang, K.L., Shackelford, J., Seo, S.Y., Pagano, J.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Hu, G., Fearon, E.R. Mol. Cell. Biol. (1999)
- Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Hu, G., Zhang, S., Vidal, M., Baer, J.L., Xu, T., Fearon, E.R. Genes Dev. (1997)
- Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Liu, J., Stevens, J., Rote, C.A., Yost, H.J., Hu, Y., Neufeld, K.L., White, R.L., Matsunami, N. Mol. Cell (2001)
- The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. Tiedt, R., Bartholdy, B.A., Matthias, G., Newell, J.W., Matthias, P. EMBO J. (2001)
- SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. Venables, J.P., Dalgliesh, C., Paronetto, M.P., Skitt, L., Thornton, J.K., Saunders, P.T., Sette, C., Jones, K.T., Elliott, D.J. Hum. Mol. Genet. (2004)
- Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Hu, G., Chung, Y.L., Glover, T., Valentine, V., Look, A.T., Fearon, E.R. Genomics (1997)
- SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Germani, A., Prabel, A., Mourah, S., Podgorniak, M.P., Di Carlo, A., Ehrlich, R., Gisselbrecht, S., Varin-Blank, N., Calvo, F., Bruzzoni-Giovanelli, H. Oncogene (2003)
- Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene. Medhioub, M., Vaury, C., Hamelin, R., Thomas, G. Int. J. Cancer (2000)
- Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation. Avraham, E., Szargel, R., Eyal, A., Rott, R., Engelender, S. J. Biol. Chem. (2005)
- Siah-1 facilitates ubiquitination and degradation of synphilin-1. Nagano, Y., Yamashita, H., Takahashi, T., Kishida, S., Nakamura, T., Iseki, E., Hattori, N., Mizuno, Y., Kikuchi, A., Matsumoto, M. J. Biol. Chem. (2003)
- SIAH1 causes growth arrest and apoptosis in hepatoma cells through beta-catenin degradation-dependent and -independent mechanisms. Yoshibayashi, H., Okabe, H., Satoh, S., Hida, K., Kawashima, K., Hamasu, S., Nomura, A., Hasegawa, S., Ikai, I., Sakai, Y. Oncol. Rep. (2007)
- Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. Habelhah, H., Laine, A., Erdjument-Bromage, H., Tempst, P., Gershwin, M.E., Bowtell, D.D., Ronai, Z. J. Biol. Chem. (2004)
- Inactivating mutations of the Siah-1 gene in gastric cancer. Kim, C.J., Cho, Y.G., Park, C.H., Jeong, S.W., Nam, S.W., Kim, S.Y., Lee, S.H., Yoo, N.J., Lee, J.Y., Park, W.S. Oncogene (2004)
- Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Park, S., Gwak, J., Cho, M., Song, T., Won, J., Kim, D.E., Shin, J.G., Oh, S. Mol. Pharmacol. (2006)
- Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. Johnsen, S.A., Subramaniam, M., Monroe, D.G., Janknecht, R., Spelsberg, T.C. J. Biol. Chem. (2002)
- The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome. Fanelli, M., Fantozzi, A., De Luca, P., Caprodossi, S., Matsuzawa, S., Lazar, M.A., Pelicci, P.G., Minucci, S. J. Biol. Chem. (2004)
- Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. Iwai, A., Marusawa, H., Matsuzawa, S., Fukushima, T., Hijikata, M., Reed, J.C., Shimotohno, K., Chiba, T. Oncogene (2004)
- Regulation of BOB.1/OBF.1 stability by SIAH. Boehm, J., He, Y., Greiner, A., Staudt, L., Wirth, T. EMBO J. (2001)
- Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Okabe, H., Satoh, S., Furukawa, Y., Kato, T., Hasegawa, S., Nakajima, Y., Yamaoka, Y., Nakamura, Y. Cancer Res. (2003)
- Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). Matsuzawa, S., Li, C., Ni, C.Z., Takayama, S., Reed, J.C., Ely, K.R. J. Biol. Chem. (2003)
- Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors. Moriyoshi, K., Iijima, K., Fujii, H., Ito, H., Cho, Y., Nakanishi, S. Proc. Natl. Acad. Sci. U.S.A. (2004)