Gene Review:
SKIL - SKI-like proto-oncogene
Homo sapiens
Synonyms:
SNO, Ski-like protein, Ski-related oncogene, Ski-related protein, SnoA, ...
- A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Wilkinson, D.S., Ogden, S.K., Stratton, S.A., Piechan, J.L., Nguyen, T.T., Smulian, G.A., Barton, M.C. Mol. Cell. Biol. (2005)
- Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. Zhang, L., Sato, E., Amagasaki, K., Nakao, A., Naganuma, H. J. Neurosurg. (2006)
- SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus. Imoto, I., Pimkhaokham, A., Fukuda, Y., Yang, Z.Q., Shimada, Y., Nomura, N., Hirai, H., Imamura, M., Inazawa, J. Biochem. Biophys. Res. Commun. (2001)
- Dual role of SnoN in mammalian tumorigenesis. Zhu, Q., Krakowski, A.R., Dunham, E.E., Wang, L., Bandyopadhyay, A., Berdeaux, R., Martin, G.S., Sun, L., Luo, K. Mol. Cell. Biol. (2007)
- Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q., Luo, K. Science (1999)
- Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Stroschein, S.L., Bonni, S., Wrana, J.L., Luo, K. Genes Dev. (2001)
- The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Wan, Y., Liu, X., Kirschner, M.W. Mol. Cell (2001)
- Cytotoxicity of fumonisin B1, diethylnitrosamine, and catechol on the SNO esophageal cancer cell line. Myburg, R.B., Dutton, M.F., Chuturgoon, A.A. Environ. Health Perspect. (2002)
- S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Gandley, R.E., Tyurin, V.A., Huang, W., Arroyo, A., Daftary, A., Harger, G., Jiang, J., Pitt, B., Taylor, R.N., Hubel, C.A., Kagan, V.E. Hypertension (2005)
- Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Krakowski, A.R., Laboureau, J., Mauviel, A., Bissell, M.J., Luo, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- SnoN is a cell type-specific mediator of transforming growth factor-beta responses. Sarker, K.P., Wilson, S.M., Bonni, S. J. Biol. Chem. (2005)
- An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells. Hu, L.Y., Tepper, C.G., Lo, S.H., Lin, W.C. Gene Expr. (2006)
- Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN. Stegmüller, J., Konishi, Y., Huynh, M.A., Yuan, Z., Dibacco, S., Bonni, A. Neuron (2006)
- Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells. Zhu, Q., Pearson-White, S., Luo, K. Mol. Cell. Biol. (2005)
- SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno. Pearson-White, S. Nucleic Acids Res. (1993)
- TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-beta Signaling by Targeting SnoN Oncoprotein for Degradation. Kajino, T., Omori, E., Ishii, S., Matsumoto, K., Ninomiya-Tsuji, J. J. Biol. Chem. (2007)
- Downregulation of Ski and SnoN co-repressors by anisomycin. Vázquez-Macías, A., Ruíz-Mendoza, A.B., Fonseca-Sánchez, M.A., Briones-Orta, M.A., Macías-Silva, M. FEBS Lett. (2005)
- Buried s-nitrosocysteine revealed in crystal structures of human thioredoxin(,). Weichsel, A., Brailey, J.L., Montfort, W.R. Biochemistry (2007)
- Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor. Tan, R., Zhang, X., Yang, J., Li, Y., Liu, Y. J. Am. Soc. Nephrol. (2007)
- The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. He, J., Tegen, S.B., Krawitz, A.R., Martin, G.S., Luo, K. J. Biol. Chem. (2003)
- Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. Mizuide, M., Hara, T., Furuya, T., Takeda, M., Kusanagi, K., Inada, Y., Mori, M., Imamura, T., Miyazawa, K., Miyazono, K. J. Biol. Chem. (2003)
- SnoN co-repressor binds and represses smad7 gene promoter. Briones-Orta, M.A., Sosa-Garrocho, M., Moreno-Alvarez, P., Fonseca-Sánchez, M.A., Macías-Silva, M. Biochem. Biophys. Res. Commun. (2006)
- Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Komuro, A., Imamura, T., Saitoh, M., Yoshida, Y., Yamori, T., Miyazono, K., Miyazawa, K. Oncogene (2004)
- Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation. Wrighton, K.H., Liang, M., Bryan, B., Luo, K., Liu, M., Feng, X.H., Lin, X. J. Biol. Chem. (2007)
- TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Bonni, S., Wang, H.R., Causing, C.G., Kavsak, P., Stroschein, S.L., Luo, K., Wrana, J.L. Nat. Cell Biol. (2001)
- The 26S proteasome system in the signaling pathways of TGF-beta superfamily. Wang, T. Front. Biosci. (2003)
- Downregulation of SnoN Expression in Obstructive Nephropathy Is Mediated by an Enhanced Ubiquitin-Dependent Degradation. Tan, R., Zhang, J., Tan, X., Zhang, X., Yang, J., Liu, Y. J. Am. Soc. Nephrol. (2006)
- Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. Fukuchi, M., Nakajima, M., Fukai, Y., Miyazaki, T., Masuda, N., Sohda, M., Manda, R., Tsukada, K., Kato, H., Kuwano, H. Int. J. Cancer (2004)
- Abnormal expression of Smurf2 during the process of rat liver fibrosis. Cai, Y., Shen, X.Z., Zhou, C.H., Wang, J.Y. Chinese journal of digestive diseases. (2006)
- Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas. Zhang, F., Lundin, M., Ristimäki, A., Heikkilä, P., Lundin, J., Isola, J., Joensuu, H., Laiho, M. Cancer Res. (2003)