Gene Review:
BMP2 - bone morphogenetic protein 2
Homo sapiens
Synonyms:
BDA2, BMP-2, BMP-2A, BMP2A, Bone morphogenetic protein 2, ...
Ghosh Choudhury,
Kim,
Simon,
Wozney,
Harris,
Ghosh-Choudhury,
Abboud,
Ghosh Choundhury,
Ghosh-Choundhury,
Clement,
Marr,
Meissner,
Schwalbe,
Sebald,
Kliche,
Höffken,
Wölfl,
Wallin,
Cain,
Hutson,
Sane,
Loeser,
Zachos,
Shields,
Bertone,
Maguer-Satta,
Bartholin,
Jeanpierre,
Ffrench,
Martel,
Magaud,
Rimokh,
Ripamonti,
Crooks,
Petit,
Rueger,
Eliseev,
Schwarz,
Zuscik,
O'Keefe,
Drissi,
Rosier,
Weese-Mayer,
Berry-Kravis,
Zhou,
Maher,
Curran,
Silvestri,
Marazita,
Ryoo,
Lee,
Kim,
- BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Waite, K.A., Eng, C. Hum. Mol. Genet. (2003)
- Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. Zhu, W., Rawlins, B.A., Boachie-Adjei, O., Myers, E.R., Arimizu, J., Choi, E., Lieberman, J.R., Crystal, R.G., Hidaka, C. J. Bone Miner. Res. (2004)
- Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath, L.G., Henshall, S.M., Kench, J.G., Turner, J.J., Golovsky, D., Brenner, P.C., O'Neill, G.F., Kooner, R., Stricker, P.D., Grygiel, J.J., Sutherland, R.L. Prostate (2004)
- Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. Weese-Mayer, D.E., Berry-Kravis, E.M., Zhou, L., Maher, B.S., Curran, M.E., Silvestri, J.M., Marazita, M.L. Pediatr. Res. (2004)
- Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. Clement, J.H., Marr, N., Meissner, A., Schwalbe, M., Sebald, W., Kliche, K.O., Höffken, K., Wölfl, S. J. Cancer Res. Clin. Oncol. (2000)
- BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Tsuji, K., Bandyopadhyay, A., Harfe, B.D., Cox, K., Kakar, S., Gerstenfeld, L., Einhorn, T., Tabin, C.J., Rosen, V. Nat. Genet. (2006)
- Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Morrison, S.J., Perez, S.E., Qiao, Z., Verdi, J.M., Hicks, C., Weinmaster, G., Anderson, D.J. Cell (2000)
- The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Kume, T., Deng, K.Y., Winfrey, V., Gould, D.B., Walter, M.A., Hogan, B.L. Cell (1998)
- MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Hoodless, P.A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M.B., Attisano, L., Wrana, J.L. Cell (1996)
- Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Sugiyama, M., Kodama, T., Konishi, K., Abe, K., Asami, S., Oikawa, S. Biochem. Biophys. Res. Commun. (2000)
- Alteration of gene expression in response to bone morphogenetic protein-2 in androgen-dependent human prostate cancer LNCaP cells. Kumagai, T., Tomari, K., Shimizu, T., Takeda, K. Int. J. Mol. Med. (2006)
- Bone morphogenetic protein-2 induces hypophosphorylation of Rb protein and repression of E2F in androgen-treated LNCaP human prostate cancer cells. Tomari, K., Kumagai, T., Shimizu, T., Takeda, K. Int. J. Mol. Med. (2005)
- Specific induction of apoptosis in P19 embryonal carcinoma cells by retinoic acid and BMP2 or BMP4. Glozak, M.A., Rogers, M.B. Dev. Biol. (1996)
- Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis. Kato, C., Miyazaki, K., Nakagawa, A., Ohira, M., Nakamura, Y., Ozaki, T., Imai, T., Nakagawara, A. Int. J. Cancer (2004)
- BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network. Hassan, M.Q., Tare, R.S., Lee, S.H., Mandeville, M., Morasso, M.I., Javed, A., van Wijnen, A.J., Stein, J.L., Stein, G.S., Lian, J.B. J. Biol. Chem. (2006)
- Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase. Ghosh Choudhury, G., Kim, Y.S., Simon, M., Wozney, J., Harris, S., Ghosh-Choudhury, N., Abboud, H.E., Ghosh Choundhury, G., Ghosh-Choundhury, N. J. Biol. Chem. (1999)
- A polymorphism in a conserved posttranscriptional regulatory motif alters bone morphogenetic protein 2 (BMP2) RNA:protein interactions. Fritz, D.T., Jiang, S., Xu, J., Rogers, M.B. Mol. Endocrinol. (2006)
- Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family. Maguer-Satta, V., Bartholin, L., Jeanpierre, S., Ffrench, M., Martel, S., Magaud, J.P., Rimokh, R. Exp. Cell Res. (2003)
- Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Truksa, J., Peng, H., Lee, P., Beutler, E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Eliseev, R.A., Schwarz, E.M., Zuscik, M.J., O'Keefe, R.J., Drissi, H., Rosier, R.N. Exp. Cell Res. (2006)
- Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Chen, Y., Luk, K.D., Cheung, K.M., Xu, R., Lin, M.C., Lu, W.W., Leong, J.C., Kung, H.F. Gene Ther. (2003)
- Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. Bleuming, S.A., Kodach, L.L., Garcia Leon, M.J., Richel, D.J., Peppelenbosch, M.P., Reitsma, P.H., Hardwick, J.C., van den Brink, G.R. J. Pathol. (2006)
- Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Xia, Y., Sidis, Y., Mukherjee, A., Samad, T.A., Brenner, G., Woolf, C.J., Lin, H.Y., Schneyer, A. Endocrinology (2005)
- Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. Bae, J.S., Gutierrez, S., Narla, R., Pratap, J., Devados, R., van Wijnen, A.J., Stein, J.L., Stein, G.S., Lian, J.B., Javed, A. J. Cell. Biochem. (2007)
- Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. Kawano, H., Nakatani, T., Mori, T., Ueno, S., Fukaya, M., Abe, A., Kobayashi, M., Toda, F., Watanabe, M., Matsuoka, I. Brain Res. Mol. Brain Res. (2004)
- Lack of aberrations of the BMP4, BMP2, and PTX1 genes in a patient with pituitary hypoplasia, os odontoideum, renal dysplasia, and right leg anomalies. Goto, M., Takita, J., Hashimoto, N., Tateshita, F., Toyoji, H., Kato, H., Egi, S., Hayashi, Y. Int. J. Mol. Med. (2002)
- Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulosa cells, and localization of BMP receptors in the ovary by immunohistochemistry. Souza, C.J., Campbell, B.K., McNeilly, A.S., Baird, D.T. Reproduction (2002)
- Evidence that human bone cells in culture contain binding sites for osteogenic protein-1. Malpe, R., Baylink, D.J., Sampath, T.K., Mohan, S. Biochem. Biophys. Res. Commun. (1994)
- Modulation of the binding of matrix Gla protein (MGP) to bone morphogenetic protein-2 (BMP-2). Wallin, R., Cain, D., Hutson, S.M., Sane, D.C., Loeser, R. Thromb. Haemost. (2000)
- Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Ryoo, H.M., Lee, M.H., Kim, Y.J. Gene (2006)
- BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. Kirsch, T., Nickel, J., Sebald, W. EMBO J. (2000)
- BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression. Hayashi, H., Ishisaki, A., Suzuki, M., Imamura, T. J. Cell. Sci. (2001)
- Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process. Xue, W., Wallin, R., Olmsted-Davis, E.A., Borrás, T. Invest. Ophthalmol. Vis. Sci. (2006)
- Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells. Marrony, S., Bassilana, F., Seuwen, K., Keller, H. Bone (2003)
- Gene-mediated osteogenic differentiation of stem cells by bone morphogenetic proteins-2 or -6. Zachos, T.A., Shields, K.M., Bertone, A.L. J. Orthop. Res. (2006)
- Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus). Ripamonti, U., Crooks, J., Petit, J.C., Rueger, D.C. Eur. J. Oral Sci. (2001)
- Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing. Bouletreau, P.J., Warren, S.M., Spector, J.A., Peled, Z.M., Gerrets, R.P., Greenwald, J.A., Longaker, M.T. Plast. Reconstr. Surg. (2002)
- Regulation of Bone Morphogenetic Protein-4 by Matrix GLA Protein in Vascular Endothelial Cells Involves Activin-like Kinase Receptor 1. Yao, Y., Zebboudj, A.F., Shao, E., Perez, M., Bostr??m, K. J. Biol. Chem. (2006)
- Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Barbara, N.P., Wrana, J.L., Letarte, M. J. Biol. Chem. (1999)
- Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Zhu, W., Kim, J., Cheng, C., Rawlins, B.A., Boachie-Adjei, O., Crystal, R.G., Hidaka, C. Bone (2006)
- Regulatory role of endothelium in the expression of genes affecting arterial calcification. Cola, C., Almeida, M., Li, D., Romeo, F., Mehta, J.L. Biochem. Biophys. Res. Commun. (2004)