Gene Review:
BMP4 - bone morphogenetic protein 4
Homo sapiens
Synonyms:
BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, ...
- Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Rothhammer, T., Poser, I., Soncin, F., Bataille, F., Moser, M., Bosserhoff, A.K. Cancer Res. (2005)
- Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. Sorescu, G.P., Sykes, M., Weiss, D., Platt, M.O., Saha, A., Hwang, J., Boyd, N., Boo, Y.C., Vega, J.D., Taylor, W.R., Jo, H. J. Biol. Chem. (2003)
- Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. Shepherd, T.G., Nachtigal, M.W. Endocrinology (2003)
- BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells. Buckley, S., Shi, W., Driscoll, B., Ferrario, A., Anderson, K., Warburton, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation. Shore, E.M., Xu, M., Shah, P.B., Janoff, H.B., Hahn, G.V., Deardorff, M.A., Sovinsky, L., Spinner, N.B., Zasloff, M.A., Wozney, J.M., Kaplan, F.S. Calcif. Tissue Int. (1998)
- Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and -5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions. Deininger, M., Meyermann, R., Schluesener, H. Acta Neuropathol. (1995)
- Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. Shafritz, A.B., Shore, E.M., Gannon, F.H., Zasloff, M.A., Taub, R., Muenke, M., Kaplan, F.S. N. Engl. J. Med. (1996)
- Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Liem, K.F., Tremml, G., Roelink, H., Jessell, T.M. Cell (1995)
- Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Bushdid, P.B., Brantley, D.M., Yull, F.E., Blaeuer, G.L., Hoffman, L.H., Niswander, L., Kerr, L.D. Nature (1998)
- A human Mad protein acting as a BMP-regulated transcriptional activator. Liu, F., Hata, A., Baker, J.C., Doody, J., Cárcamo, J., Harland, R.M., Massagué, J. Nature (1996)
- Specific induction of apoptosis in P19 embryonal carcinoma cells by retinoic acid and BMP2 or BMP4. Glozak, M.A., Rogers, M.B. Dev. Biol. (1996)
- Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. Peng, H., Wright, V., Usas, A., Gearhart, B., Shen, H.C., Cummins, J., Huard, J. J. Clin. Invest. (2002)
- Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. Frank, N.Y., Kho, A.T., Schatton, T., Murphy, G.F., Molloy, M.J., Zhan, Q., Ramoni, M.F., Frank, M.H., Kohane, I.S., Gussoni, E. J. Cell Biol. (2006)
- Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Padgett, R.W., Wozney, J.M., Gelbart, W.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Truksa, J., Peng, H., Lee, P., Beutler, E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage. Shou, J., Murray, R.C., Rim, P.C., Calof, A.L. Development (2000)
- The molecular basis of lung morphogenesis. Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K.D., Cardoso, W.V. Mech. Dev. (2000)
- Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Sorescu, G.P., Song, H., Tressel, S.L., Hwang, J., Dikalov, S., Smith, D.A., Boyd, N.L., Platt, M.O., Lassègue, B., Griendling, K.K., Jo, H. Circ. Res. (2004)
- Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes. Helvering, L.M., Sharp, R.L., Ou, X., Geiser, A.G. Gene (2000)
- Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells. Vogt, R.R., Unda, R., Yeh, L.C., Vidro, E.K., Lee, J.C., Tsin, A.T. J. Cell. Biochem. (2006)
- Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. Nohno, T., Ishikawa, T., Saito, T., Hosokawa, K., Noji, S., Wolsing, D.H., Rosenbaum, J.S. J. Biol. Chem. (1995)
- Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen. Paralkar, V.M., Weeks, B.S., Yu, Y.M., Kleinman, H.K., Reddi, A.H. J. Cell Biol. (1992)
- Regulation of Bone Morphogenetic Protein-4 Activity by Sequence Elements within the Prodomain. Sopory, S., Nelsen, S.M., Degnin, C., Wong, C., Christian, J.L. J. Biol. Chem. (2006)
- Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro. Nakayama, N., Lee, J., Chiu, L. Blood (2000)
- Regulation of Bone Morphogenetic Protein-4 by Matrix GLA Protein in Vascular Endothelial Cells Involves Activin-like Kinase Receptor 1. Yao, Y., Zebboudj, A.F., Shao, E., Perez, M., Bostr??m, K. J. Biol. Chem. (2006)
- BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Jeffery, T.K., Upton, P.D., Trembath, R.C., Morrell, N.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- The Role of BMP-6, IL-6, and BMP-4 in Mesenchymal Stem Cell-Dependent Bone Development: Effects on Osteoblastic Differentiation Induced by Parathyroid Hormone and Vitamin D(3). Sammons, J., Ahmed, N., El-Sheemy, M., Hassan, H.T. Stem cells and development. (2004)
- Bone morphogenic protein (Smad)-mediated repression of proopiomelanocortin transcription by interference with Pitx/Tpit activity. Nudi, M., Ouimette, J.F., Drouin, J. Mol. Endocrinol. (2005)
- Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells. Ro, T.B., Holt, R.U., Brenne, A.T., Hjorth-Hansen, H., Waage, A., Hjertner, O., Sundan, A., Borset, M. Oncogene (2004)
- Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP). Fiori, J.L., Billings, P.C., de la Peña, L.S., Kaplan, F.S., Shore, E.M. J. Bone Miner. Res. (2006)
- BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. Su, D., Zhu, S., Han, X., Feng, Y., Huang, H., Ren, G., Pan, L., Zhang, Y., Lu, J., Huang, B. J. Biol. Chem. (2009)
- Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. Fan, J., Shen, H., Sun, Y., Li, P., Burczynski, F., Namaka, M., Gong, Y. J. Cell. Physiol. (2006)
- Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). Felder, B., Stegmann, K., Schultealbert, A., Geller, F., Strehl, E., Ermert, A., Koch, M.C. Eur. J. Hum. Genet. (2002)
- Transforming growth factor-beta and bone morphogenetic proteins: cooperative players in chick and murine programmed retinal cell death. Franke, A.G., Gubbe, C., Beier, M., Duenker, N. J. Comp. Neurol. (2006)