Gene Review:
SLC3A2 - solute carrier family 3 (amino acid...
Homo sapiens
Synonyms:
4F2, 4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, 4F2HC, 4F2hc, ...
- L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Nawashiro, H., Otani, N., Shinomiya, N., Fukui, S., Ooigawa, H., Shima, K., Matsuo, H., Kanai, Y., Endou, H. Int. J. Cancer (2006)
- Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Okamoto, Y., Sakata, M., Ogura, K., Yamamoto, T., Yamaguchi, M., Tasaka, K., Kurachi, H., Tsurudome, M., Murata, Y. Am. J. Physiol., Cell Physiol. (2002)
- New glycoprotein-associated amino acid transporters. Verrey, F., Jack, D.L., Paulsen, I.T., Saier, M.H., Pfeiffer, R. J. Membr. Biol. (1999)
- Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions. Kim, d.o. .K., Ahn, S.G., Park, J.C., Kanai, Y., Endou, H., Yoon, J.H. Anticancer Res. (2004)
- Beta1 integrins show specific association with CD98 protein in low density membranes. Kolesnikova, T.V., Mannion, B.A., Berditchevski, F., Hemler, M.E. BMC Biochem. (2001)
- Transporters for cationic amino acids in animal cells: discovery, structure, and function. Devés, R., Boyd, C.A. Physiol. Rev. (1998)
- Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P.J., Loffing, J., Shoemaker, C.B., Verrey, F. Nature (1998)
- Complementation of dominant suppression implicates CD98 in integrin activation. Fenczik, C.A., Sethi, T., Ramos, J.W., Hughes, P.E., Ginsberg, M.H. Nature (1997)
- Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98. Chandrasekaran, S., Guo, N.H., Rodrigues, R.G., Kaiser, J., Roberts, D.D. J. Biol. Chem. (1999)
- Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. Gottesdiener, K.M., Karpinski, B.A., Lindsten, T., Strominger, J.L., Jones, N.H., Thompson, C.B., Leiden, J.M. Mol. Cell. Biol. (1988)
- The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. Cho, J.Y., Fox, D.A., Horejsi, V., Sagawa, K., Skubitz, K.M., Katz, D.R., Chain, B. Blood (2001)
- Multiple pathways for cationic amino Acid transport in rat seminiferous tubule cells. Cérec, V., Piquet-Pellorce, C., Aly, H.A., Touzalin, A.M., Jégou, B., Bauché, F. Biol. Reprod. (2007)
- Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. Pineda, M., Fernández, E., Torrents, D., Estévez, R., López, C., Camps, M., Lloberas, J., Zorzano, A., Palacín, M. J. Biol. Chem. (1999)
- The amino acid transporter asc-1 is not involved in cystinuria. Pineda, M., Font, M., Bassi, M.T., Manzoni, M., Borsani, G., Marigo, V., Fernández, E., Río, R.M., Purroy, J., Zorzano, A., Nunes, V., Palacín, M. Kidney Int. (2004)
- Function and structure of heterodimeric amino acid transporters. Wagner, C.A., Lang, F., Bröer, S. Am. J. Physiol., Cell Physiol. (2001)
- CD98hc (SLC3A2) mediates integrin signaling. Feral, C.C., Nishiya, N., Fenczik, C.A., Stuhlmann, H., Slepak, M., Ginsberg, M.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance. Torrents, D., Estévez, R., Pineda, M., Fernández, E., Lloberas, J., Shi, Y.B., Zorzano, A., Palacín, M. J. Biol. Chem. (1998)
- Transcriptional regulation of the LAT-1/CD98 light chain. Padbury, J.F., Diah, S.K., McGonnigal, B., Miller, C., Fugere, C., Kuzniar, M., Thompson, N.L. Biochem. Biophys. Res. Commun. (2004)
- Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. Bassi, M.T., Gasol, E., Manzoni, M., Pineda, M., Riboni, M., Martín, R., Zorzano, A., Borsani, G., Palacín, M. Pflugers Arch. (2001)
- SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Bassi, M.T., Sperandeo, M.P., Incerti, B., Bulfone, A., Pepe, A., Surace, E.M., Gattuso, C., De Grandi, A., Buoninconti, A., Riboni, M., Manzoni, M., Andria, G., Ballabio, A., Borsani, G., Sebastio, G. Genomics (1999)
- Cystinuria calls for heteromultimeric amino acid transporters. Palacín, M., Estévez, R., Zorzano, A. Curr. Opin. Cell Biol. (1998)
- CD98 modulates integrin beta1 function in polarized epithelial cells. Cai, S., Bulus, N., Fonseca-Siesser, P.M., Chen, D., Hanks, S.K., Pozzi, A., Zent, R. J. Cell. Sci. (2005)
- Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex. Møller, L.B., Paulsen, M., Koch, R., Moats, R., Guldberg, P., Güttler, F. Mol. Genet. Metab. (2005)
- xCt cystine transporter expression in HEK293 cells: pharmacology and localization. Shih, A.Y., Murphy, T.H. Biochem. Biophys. Res. Commun. (2001)
- Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion. Posillico, J.T., Srikanta, S., Eisenbarth, G., Quaranta, V., Kajiji, S., Brown, E.M. J. Clin. Endocrinol. Metab. (1987)
- Heteromeric amino acid transporters explain inherited aminoacidurias. Palacín, M., Bertran, J., Zorzano, A. Curr. Opin. Nephrol. Hypertens. (2000)
- Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta. Ritchie, J.W., Taylor, P.M. Biochem. J. (2001)
- Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2. Lumadue, J.A., Glick, A.B., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Quackenbush, E., Clabby, M., Gottesdiener, K.M., Barbosa, J., Jones, N.H., Strominger, J.L., Speck, S., Leiden, J.M. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells. Kudo, Y., Boyd, C.A., Millo, J., Sargent, I.L., Redman, C.W. J. Physiol. (Lond.) (2003)