Gene Review:
WNK4 - WNK lysine deficient protein kinase 4
Homo sapiens
Synonyms:
PHA2B, PRKWNK4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, Serine/threonine-protein kinase WNK4
- Properties of WNK1 and implications for other family members. Lenertz, L.Y., Lee, B.H., Min, X., Xu, B.E., Wedin, K., Earnest, S., Goldsmith, E.J., Cobb, M.H. J. Biol. Chem. (2005)
- Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Veríssimo, F., Silva, E., Morris, J.D., Pepperkok, R., Jordan, P. Oncogene (2006)
- Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. Kokubo, Y., Kamide, K., Inamoto, N., Tanaka, C., Banno, M., Takiuchi, S., Kawano, Y., Tomoike, H., Miyata, T. J. Hum. Genet. (2004)
- Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. Mayan, H., Munter, G., Shaharabany, M., Mouallem, M., Pauzner, R., Holtzman, E.J., Farfel, Z. J. Clin. Endocrinol. Metab. (2004)
- Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes. Kamide, K., Takiuchi, S., Tanaka, C., Miwa, Y., Yoshii, M., Horio, T., Mannami, T., Kokubo, Y., Tomoike, H., Kawano, Y., Miyata, T. Am. J. Hypertens. (2004)
- A WNK in the kidney controls blood pressure. Coffman, T.M. Nat. Genet. (2006)
- Human hypertension caused by mutations in WNK kinases. Wilson, F.H., Disse-Nicodème, S., Choate, K.A., Ishikawa, K., Nelson-Williams, C., Desitter, I., Gunel, M., Milford, D.V., Lipkin, G.W., Achard, J.M., Feely, M.P., Dussol, B., Berland, Y., Unwin, R.J., Mayan, H., Simon, D.B., Farfel, Z., Jeunemaitre, X., Lifton, R.P. Science (2001)
- Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. Yang, C.L., Zhu, X., Wang, Z., Subramanya, A.R., Ellison, D.H. J. Clin. Invest. (2005)
- WNK kinases regulate thiazide-sensitive Na-Cl cotransport. Yang, C.L., Angell, J., Mitchell, R., Ellison, D.H. J. Clin. Invest. (2003)
- WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. Kahle, K.T., Gimenez, I., Hassan, H., Wilson, F.H., Wong, R.D., Forbush, B., Aronson, P.S., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- WNK kinases: molecular regulators of integrated epithelial ion transport. Kahle, K.T., Wilson, F.H., Lalioti, M., Toka, H., Qin, H., Lifton, R.P. Curr. Opin. Nephrol. Hypertens. (2004)
- WNK kinases influence TRPV4 channel function and localization. Fu, Y., Subramanya, A., Rozansky, D., Cohen, D.M. Am. J. Physiol. Renal Physiol. (2006)
- WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Jiang, Y., Ferguson, W.B., Peng, J.B. Am. J. Physiol. Renal Physiol. (2007)
- An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Ring, A.M., Leng, Q., Rinehart, J., Wilson, F.H., Kahle, K.T., Hebert, S.C., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Kahle, K.T., Wilson, F.H., Lifton, R.P. Trends Endocrinol. Metab. (2005)
- WNK kinases and the control of blood pressure. Cope, G., Golbang, A., O'Shaughnessy, K.M. Pharmacol. Ther. (2005)
- Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Yamauchi, K., Rai, T., Kobayashi, K., Sohara, E., Suzuki, T., Itoh, T., Suda, S., Hayama, A., Sasaki, S., Uchida, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Ohta, A., Yang, S.S., Rai, T., Chiga, M., Sasaki, S., Uchida, S. Biochem. Biophys. Res. Commun. (2006)
- Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. O'Reilly, M., Marshall, E., Macgillivray, T., Mittal, M., Xue, W., Kenyon, C.J., Brown, R.W. J. Am. Soc. Nephrol. (2006)
- WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Cai, H., Cebotaru, V., Wang, Y.H., Zhang, X.M., Cebotaru, L., Guggino, S.E., Guggino, W.B. Kidney Int. (2006)
- WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Subramanya, A.R., Yang, C.L., McCormick, J.A., Ellison, D.H. Kidney Int. (2006)
- Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Wilson, F.H., Kahle, K.T., Sabath, E., Lalioti, M.D., Rapson, A.K., Hoover, R.S., Hebert, S.C., Gamba, G., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield, A.V., Katyk, K., Morris, B.J. Clin. Genet. (2003)
- WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. Cope, G., Murthy, M., Golbang, A.P., Hamad, A., Liu, C.H., Cuthbert, A.W., O'Shaughnessy, K.M. J. Am. Soc. Nephrol. (2006)